Key takeaways
Doxepin (Silenor) and tasimelteon (Hetlioz) are both medications used to help with sleep problems, but they work in different ways and treat different conditions. Doxepin is a tricyclic antidepressant that is FDA-approved for treating insomnia, specifically to help you stay asleep. It is taken as a tablet 30 minutes before bedtime. Tasimelteon, on the other hand, is a melatonin receptor agonist that helps regulate sleep-wake cycles. It is FDA-approved for non-24-hour sleep-wake disorder in adults and sleep disturbances in children and adults with Smith-Magenis Syndrome (SMS). It is taken as a capsule or liquid suspension about 1 hour before bedtime. Doxepin is available as a generic, while tasimelteon capsules have a generic option, but the liquid form does not. Common side effects of doxepin include sleepiness and tiredness, while tasimelteon can cause headaches and unusual dreams. Both medications should be taken on an empty stomach. Both doxepin and tasimelteon can interact with other medications, so be sure your prescriber and pharmacist have a complete list of medications you take.
