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Lyrica vs. Pamelor

Pregabalin (Lyrica) helps treat nerve pain and fibromyalgia in adults. It can also be taken with other medications to help treat certain seizures in people 1 month and older. Pregabalin (Lyrica) comes as a capsule and oral solution in both brand-name and generic versions. The dosage depends on what condition you're treating, but it's usually taken by mouth 2 or 3 times a day. Common side effects include feeling dizzy and drowsy. This medication is a controlled substance and has interactions, like with alcohol and benzodiazepines.

• Nerve pain from diabetes (diabetic peripheral neuropathy)
• Nerve pain from shingles (postherpetic neuralgia)
• Nerve pain from spinal cord injury
• Fibromyalgia
• Partial-onset seizures

• Dizziness
• Drowsiness
• Headache
• Weight gain

• Allergic reactions and severe swelling
• Risk of suicidal thoughts and behavior
• Higher risk of side effects if you stop taking the medication too suddenly or too fast
• Slowed breathing
• Dizziness, sleepiness, and trouble concentrating
• Swelling of the arms or legs
• Weight gain
• Lower platelet levels
• Possible risk of muscle breakdown

Nortriptyline (Pamelor) is a tricyclic antidepressant (TCA). It's approved to treat depression in adults. This medication is also often prescribed off-label to treat certain types of nerve pain. Nortriptyline (Pamelor) is available as a capsule and liquid that are taken by mouth. Side effects include dry mouth, dizziness, and possible weight gain. This medication is available under the brand name Pamelor and as a generic.

• Depression

• Blurred vision
• Dry mouth
• Nausea
• Vomiting
• Stomach upset
• Loss of appetite
• Numbness in the hands or feet
• Rash
• Itching
• Changes in blood pressure

• Worsening depression and risk for suicidal thoughts and unusual behavior
• Not for use alone in bipolar disorder
• Dizziness and drowsiness
• Risk of heart problems, heart attack, or stroke
• Glaucoma