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Lyrica vs. Pristiq

Pregabalin (Lyrica) helps treat nerve pain and fibromyalgia in adults. It can also be taken with other medications to help treat certain seizures in people 1 month and older. Pregabalin (Lyrica) comes as a capsule and oral solution in both brand-name and generic versions. The dosage depends on what condition you're treating, but it's usually taken by mouth 2 or 3 times a day. Common side effects include feeling dizzy and drowsy. This medication is a controlled substance and has interactions, like with alcohol and benzodiazepines.

• Nerve pain from diabetes (diabetic peripheral neuropathy)
• Nerve pain from shingles (postherpetic neuralgia)
• Nerve pain from spinal cord injury
• Fibromyalgia
• Partial-onset seizures

• Dizziness
• Drowsiness
• Headache
• Weight gain

• Allergic reactions and severe swelling
• Risk of suicidal thoughts and behavior
• Higher risk of side effects if you stop taking the medication too suddenly or too fast
• Slowed breathing
• Dizziness, sleepiness, and trouble concentrating
• Swelling of the arms or legs
• Weight gain
• Lower platelet levels
• Possible risk of muscle breakdown

Desvenlafaxine (Pristiq) is a medication used to treat depression in adults. It's only available as a tablet that's typically taken once a day. This medication can raise your blood pressure, so it might not be the best choice if you have uncontrolled high blood pressure or heart problems.

• Depression

• Nausea (22%)
• Dizziness (13%)
• Dry mouth (11%)
• Excessive sweating (10%)
• Constipation (9%)
• Trouble sleeping (9%)
• Feeling tired (7%)
• Loss of appetite (5%)
• Sleepiness (4%)
• Low sex drive (4%)

• Suicidal thoughts and behaviors
• Serotonin syndrome
• High blood pressure
• Higher bleeding risk
• Worsening of glaucoma
• Emergence of mania
• Withdrawal symptoms
• Seizures
• Low sodium levels in the blood
• Lung problems and pneumonia