Key takeaways
Zaleplon (Sonata) and mirtazapine (Remeron) are both medications that can help with sleep, but they belong to different drug classes. Zaleplon is a non-benzodiazepine sedative-hypnotic, often called a "z-drug," and is specifically FDA-approved for treating insomnia by helping you fall asleep. Mirtazapine, on the other hand, is an antidepressant used to treat major depressive disorder (MDD) in adults, but can cause sleepiness as a side effect and is often used off-label for insomnia. Zaleplon is taken orally right before bed and works quickly, while mirtazapine is taken once daily, usually at night. Zaleplon is a controlled substance due to its potential for misuse and dependence, whereas mirtazapine is not. Common side effects of zaleplon include headache and dizziness, while mirtazapine can cause sleepiness, dry mouth, and weight gain. Both medications should not be mixed with alcohol and have a number of drug interactions. Your prescriber will work with you to determine the right medication for you.
