Key takeaways
Triazolam (Halcion) and doxepin (Sinequan) are both prescription medications that can be used to treat insomnia, although that is an off-label use for the Sinequan generic. Triazolam is a benzodiazepine, while doxepin is a tricyclic antidepressant (TCA). Triazolam is specifically FDA-approved for short-term treatment of insomnia, whereas doxepin is approved for depression and anxiety. Triazolam is taken as a single oral dose before bedtime, typically 0.25 mg, and is available as a generic. Doxepin is taken in doses ranging from 75 mg to 150 mg daily and is also available in generic form. Triazolam can cause side effects like sleepiness, headaches, and dizziness, and is a Schedule IV controlled substance because it can lead to misuse and dependence. Doxepin can cause drowsiness, dry mouth, and bluured vision and is not a controlled substance. Both medications should not be mixed with alcohol. Triazolam can cause life-threatening side effects if taken with opioids, while doxepin can increase the risk for serotonin syndrome, especially when mixed with other medications that increase serotonin.
