Key takeaways
Ramelteon (Rozerem) and tasimelteon (Hetlioz) are both melatonin receptor agonists used to help with sleep, but they have different uses and characteristics. Ramelteon is used to treat insomnia in adults. It is taken 30 minutes before bedtime and works quickly, but should not be taken with a high-fat meal. On the other hand, tasimelteon is used to help people with blindness who have non-24-hour sleep-wake disorder and those with Smith-Magenis Syndrome. Tasimelteon needs to be taken at the same time every night on an empty stomach and can take weeks to months to show effects. Both medications are not controlled substances and are not habit-forming, but they have different side effects and interactions with other medications. Ramelteon can cause dizziness and drowsiness, while tasimelteon can cause headaches, abnormal liver tests, and upper respiratory infections. Both are available as generic medications. Ramelteon comes as an oral tablet, while tasimelteon is an oral capsule. A liquid form called Hetlioz LQ is also available.
