Key takeaways
Zaleplon (Sonata) and trazodone (Desyrel) are both used to help with sleep, but they work in different ways and are used for different primary purposes. Zaleplon is a sedative-hypnotic medication specifically designed to help you fall asleep quickly, but it doesn't help you stay asleep through the night. It's a controlled substance due to its potential for abuse and dependence. On the other hand, trazodone is an atypical antidepressant primarily used to treat depression, but it is sometimes prescribed off-label for insomnia. Unlike zaleplon, trazodone is not a controlled substance and doesn't carry the same risk of dependence. Zaleplon works by affecting gamma-aminobutyric acid (GABA) receptors in the brain, while trazodone affects serotonin levels. Zaleplon is taken right before bedtime and works within 20 to 30 minutes, whereas trazodone can be taken once or several times a day, depending on the condition being treated. Both medications can cause drowsiness and should not be mixed with alcohol.
