Compare Sonata vs. Belsomra

Zaleplon (Sonata) and Belsomra (suvorexant) are both medications used to treat insomnia, but they work in different ways and have some key differences. Zaleplon is a sedative-hypnotic that helps you fall asleep by working on gamma-aminobutyric acid (GABA) receptors in your brain. It is available as a lower-cost generic and is best for short-term use, up to 30 days. On the other hand, Belsomra is an orexin receptor antagonist that helps you fall and stay asleep by blocking the action of orexin, a chemical that promotes wakefulness. Belsomra is only available as a brand-name medication, making it more expensive. Both medications can be habit-forming and are controlled substances, but Belsomra is noted for potentially causing sleep paralysis and muscle weakness in the legs. Zaleplon may cause unusual sleep behaviors like sleep-walking or sleep-driving. While both medications can cause drowsiness the next day, Belsomra is generally considered a safer option for the elderly.