Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Zaleplon (Sonata) and estazolam (formerly branded as Prosom) are both medications used to treat insomnia, but they have some key differences. Zaleplon is a non-benzodiazepine sedative-hypnotic that helps you fall asleep quickly but doesn't help you stay asleep. Estazolam , on the other hand, is a benzodiazepine that helps you both fall asleep and stay asleep. Zaleplon is only recommended for short-term use (up to 30 days) and is available as a generic. Estazolam is also meant for short-term use and is only available as a generic since the brand name is no longer on the market. Both medications can be habit-forming and may cause dependence, but estazolam has a higher risk of causing drowsiness and affecting your concentration the next day. Additionally, estazolam is not recommended for older adults due to the increased risk of falls, while zaleplon may cause fewer next-day drowsiness issues. Both medications can cause unusual sleep behaviors like sleep-walking or sleep-driving, and you should avoid alcohol and other sedatives while taking them.
Zaleplon
Estazolam (Prosom)
Zaleplon
Estazolam (Prosom)
Summary of Sonata vs. Estazolam
Summary for Sedative-hypnotic
Prescription only
Zaleplon, once sold under the brand name Sonata, is a prescription sleep medication for adults. It helps with insomnia (trouble falling asleep). It's a type of sedative-hypnotic called a non-benzodiazepine, or "z-drug." You take it by mouth right before bed or when you're already in bed and can't fall asleep. Zaleplon is a controlled substance because it has a risk of misuse and dependence. Side effects can include headache and dizziness.
Summary for Benzodiazepine
Prescription only
Estazolam (Prosom) is a sleeping pill that can help adults with insomnia fall asleep and stay asleep. It's a benzodiazepine medication that's not a first-choice treatment option for trouble sleeping, and it's only meant for short-term use since it can be habit-forming. It comes as a tablet that you take by mouth right before you get into bed. It's only available as a generic since the brand-name medication, Prosom, is no longer on the market. In addition to causing sleepiness, other common side effects can include headache, weakness, and nervousness.