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Ramelteon Coupon - Ramelteon 8mg tablet

ramelteon

Generic Rozerem
Used for Insomnia
Used for Insomnia

Ramelteon (Rozerem) is a sleeping pill used to treat insomnia in adults. It belongs to the drug class known as melatonin receptor agonists and works like melatonin. Ramelteon (Rozerem) is taken by mouth, typically about 30 minutes before bedtime. Unlike some other prescription sleep medications, ramelteon (Rozerem) isn't a controlled substance nor known to be habit-forming. Side effects of ramelteon (Rozerem) aren't common, but can include drowsiness and dizziness.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on May 5, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Ramelteon (Rozerem)?

What is Ramelteon (Rozerem) used for?

How Ramelteon (Rozerem) works

Ramelteon (Rozerem) is a melatonin receptor agonists. It acts like melatonin, a natural hormone that your body makes when it's dark. This hormone tells your body to go to sleep in order to maintain a regular sleeping cycle.

When does Ramelteon (Rozerem) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsRozerem
Drug ClassMelatonin receptor agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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$277.40(save 86.43%)
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What are the side effects of Ramelteon (Rozerem)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness (4%)
  • Sleepiness (3%)
  • Fatigue (3%)
  • Nausea (3%)
  • Worsening insomnia (3%)

Other Side Effects

  • Headache

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
When do Ramelteon (Rozerem) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Dizziness
Sleepiness
Tiredness

Source: DailyMed

More on Ramelteon (Rozerem) side effects

ramelteon: side effects ramelteon

7 Ramelteon (Rozerem) Side Effects: What to Expect When Taking This Sleeping Pill

Written by Austin Ulrich, PharmD, BCACP

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness

sleepiness or unusual drowsiness

Less common

Body aches or pain

change in taste

chills

cough

difficulty in breathing

difficulty in moving

discouragement

ear congestion

fatigue

feeling sad or empty

fever

general feeling of discomfort or illness

irritability

joint pain

loss of appetite

loss of interest or pleasure

loss of taste

loss of voice

muscle aching or cramping

muscle pain or stiffness

nasal congestion

nausea

pain in joints

runny nose

shivering

sleeplessness

sneezing

sore throat

sweating

swollen joints

trouble concentrating

trouble sleeping

unable to sleep

unusual tiredness or weakness

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Ramelteon (Rozerem)

thumbs-up

Pros

Taken by mouth

Not a controlled substance and isn't known to be habit-forming

Fewer side effects than some other sleep medications

Available as a generic medication

thumbs-down

Cons

Shouldn't take with or right after a high-fat meal

Can interact with many medications, including fluconazole, rifampin, and fluvoxamine

Not recommended for people with sleep apnea or severe liver problems

pharmacist-tips

Pharmacist tips for Ramelteon (Rozerem)

pharmacist

  • Take ramelteon (Rozerem) on an empty stomach 30 minutes before you sleep. This helps your body absorb the medication faster so that you can fall asleep sooner.

    • Swallow the ramelteon (Rozerem) tablet whole. Don't break, crush, or chew the tablets.

      • After taking ramelteon (Rozerem), make sure you are fully prepared for bed. Create a relaxing environment by turning down the lights and turning off your phone.

        • Take ramelteon (Rozerem) only if you have time to get a full night's sleep. If you don't get enough sleep, you may be less alert the next day.

          • Talk to your prescriber if you continue to have insomnia after 7 to 10 days of taking ramelteon (Rozerem) daily. There might be another condition causing your insomnia and it’s important that you get re-examined.

            • Don't drink alcohol with ramelteon (Rozerem) as it can raise your risk of experiencing side effects such as unusual behaviors or worsening depression. If you experience these side effects after taking ramelteon (Rozerem), talk to your healthcare professional (HCP) as you might need to stop taking the medication.

              • Don't drive after taking ramelteon (Rozerem) until you are fully alert. You might feel drowsy the next day after taking this medication.

                faqs

                Frequently asked questions about Ramelteon (Rozerem)

                Can I take 16 mg of ramelteon (Rozerem)?
                No, the maximum recommended dose of ramelteon (Rozerem) is 8 mg by mouth once a day. Researchers compared the effects of ramelteon (Rozerem) 8 mg with that of ramelteon (Rozerem) 16 mg. Results showed that ramelteon (Rozerem) 16 mg didn't help people sleep any better, but did lead to more side effects like fatigue, headache, and tiredness the next day.
                Is ramelteon (Rozerem) a controlled substance?
                No, ramelteon (Rozerem) isn't a controlled substance. It's not known to carry a risk of addiction or dependence.
                Is ramelteon (Rozerem) habit-forming?
                Studies show that ramelteon (Rozerem) is not habit-forming and doesn't cause withdrawal symptoms once you stop taking it.
                How quickly does ramelteon (Rozerem) work?
                Ramelteon (Rozerem) starts to work within 30 minutes, as long as you take it on an empty stomach. Food, especially those high in fat content) can slow down the time it takes the body to absorb the medication fully, which means it’ll take longer for ramelteon (Rozerem) to work.
                Does ramelteon (Rozerem) cause weight gain?
                Ramelteon (Rozerem) isn't known to cause weight gain as a side effect. But like other sleeping medications, it can cause some people to perform activities while sleeping, including preparing and eating food. And if so, the extra eating might lead to weight gain. It's important to be mindful of this rare side effect and alert loved ones of this potential behavior as you're taking this medication.
                Does ramelteon (Rozerem) cause hair loss?
                Hair loss isn't a commonly reported side effect of ramelteon (Rozerem). If you're experiencing hair loss, tell your prescriber about all the medications you're taking so they can help determine the cause.
                Is ramelteon (Rozerem) over the counter?
                No, ramelteon (Rozerem) is only available with a prescription from a healthcare professional (HCP). If you're looking for an over-the-counter option to help you sleep, ask your HCP about melatonin. Ramelteon (Rozerem) works like melatonin, so this might be an alternative for you.
                Can I take ramelteon (Rozerem) and melatonin together?
                No, don't take ramelteon (Rozerem) and melatonin together, especially without first checking in with your sleep specialist. These medications work similarly in the same areas of the brain to help you maintain a regular sleep cycle. Taking them together can cause you to have too much melatonin in your system and thus have more side effects like fatigue, headache, and sleepiness the next day.
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                What are the risks and warnings for Ramelteon (Rozerem)?

                Ramelteon (Rozerem) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Severe allergic reaction

                In rare cases, ramelteon (Rozerem) can cause swelling of the face, lips, tongue, or throat due to an allergic reaction. Some people also have nausea and vomiting. This can happen either after your first dose or after taking multiple doses. If you have any of these symptoms, stop taking the medication and get emergency medical help right away.

                risk-warning

                Changes in behavior and unusual thoughts

                • Risk factors: Taking ramelteon (Rozerem) with alcohol | Taking ramelteon (Rozerem) with other medications that slow brain activity (CNS depressants) | History of depression

                  People taking ramelteon (Rozerem) have experienced changes in their behavior or have had unusual thoughts. This includes hallucinations, worsening depression, and suicidal thoughts. People have also done activities in their sleep while taking ramelteon (Rozerem) that they're unaware of or don’t remember, such as driving, cooking, eating, and making phone calls. If this happens, talk to your healthcare professional (HCP) right away, as you'll likely need to stop taking the medication.

                  risk-warning

                  Other causes of insomnia

                  If your insomnia worsens or isn’t getting better after 7 to 10 days of taking ramelteon (Rozerem), it might be caused by another condition. It’s important to talk to your HCP to re-examine the cause of your insomnia so that they can help find the best treatment for you.

                  risk-warning

                  Caution while driving

                  Ramelteon (Rozerem) is taken to help you sleep. Don’t drive or do anything that requires concentration after taking ramelteon (Rozerem). Also, don't take ramelteon (Rozerem) any sooner than 30 minutes before you're about to go to bed. Wait until you're ready to go to sleep before you take your dose. Then, you should still avoid driving or doing other dangerous activities until you feel fully awake.

                  risk-warning

                  Hormonal changes

                  Ramelteon (Rozerem) can cause changes in your hormones, including lowering your testosterone level and raising your prolactin level. It's unclear whether these changes will lead to any physical side effects. Talk to your prescriber if this is a concern for you.

                  dosage

                  Ramelteon (Rozerem) dosage forms

                  The average cost for 30 tablets of 8mg of Ramelteon (Rozerem) is $37.64 with a free GoodRx coupon. This is 86.43% off the average retail price of $277.40.
                  tablet
                  Tablet
                  DosageQuantityPrice as low asPrice per unit
                  8mg30 tablets$37.64$1.25

                  Typical dosing for Ramelteon (Rozerem)

                  • Adults: The typical dose is 8 mg by mouth within 30 minutes of bedtime. Don't take ramelteon (Rozerem) with or right after a high-fat meal.

                  interactions

                  Interactions between Ramelteon (Rozerem) and other drugs

                  Ramelteon (Rozerem) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Ramelteon (Rozerem). Please note that only the generic name of each medication is listed below.

                  Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                  Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                  Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                  drug-cost

                  How much does Ramelteon (Rozerem) cost?

                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                  Rozerem (brand)
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                  Ramelteon (Rozerem) (generic)
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                  contraindications-icon

                  Ramelteon (Rozerem) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Ramelteon (Rozerem) will not be safe for you to take.

                  • Taking fluvoxamine at the same time as ramelteon (Rozerem)

                  alternatives

                  What are alternatives to Ramelteon (Rozerem)?

                  There are a number of medications that your doctor can prescribe in place of Ramelteon (Rozerem). Compare a few possible alternatives below.
                  Ramelteon (Rozerem)
                  Used for:
                  $37.64 Lowest GoodRx priceView Prices
                  Melatonin
                  Used for:
                  $4.27 Lowest GoodRx priceView Prices
                  Doxylamine (Unisom SleepTabs)
                  Used for:
                  $4.86 Lowest GoodRx priceView Prices
                  images

                  Ramelteon (Rozerem) images

                  Yellow Round Ac 414 - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Ac 414".Yellow Round Ac 414 - Ramelteon 8mg Tablet
                  Yellow Round Rm - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Rm".Yellow Round Rm - Ramelteon 8mg Tablet
                  Yellow Round Rm - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Rm".Yellow Round Rm - Ramelteon 8mg Tablet
                  Yellow-Orange Round R And 8 - Ramelteon 8mg Tablet
                  This medicine is Yellow-Orange, Round Tablet Imprinted With "8" And "R".Yellow-Orange Round R And 8 - Ramelteon 8mg Tablet
                  Yellow Round 5 And I3 - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "I3" And "5".Yellow Round 5 And I3 - Ramelteon 8mg Tablet
                  Yellow Round 5 And I3 - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "I3" And "5".Yellow Round 5 And I3 - Ramelteon 8mg Tablet
                  Yellow Round 8 And Rt - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Rt" And "8".Yellow Round 8 And Rt - Ramelteon 8mg Tablet
                  Yellow Round 8 And Rt - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Rt" And "8".Yellow Round 8 And Rt - Ramelteon 8mg Tablet
                  Yellow-Orange Round E And 8 - Ramelteon 8mg Tablet
                  This medicine is Yellow-Orange, Round Tablet Imprinted With "E" And "8".Yellow-Orange Round E And 8 - Ramelteon 8mg Tablet
                  Yellow-Orange Round E And 8 - Ramelteon 8mg Tablet
                  This medicine is Yellow-Orange, Round Tablet Imprinted With "E" And "8".Yellow-Orange Round E And 8 - Ramelteon 8mg Tablet
                  Yellow Round G 28 - Ramelteon 8mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "G 28".Yellow Round G 28 - Ramelteon 8mg Tablet
                  Beige Round 1344 - Ramelteon 8mg Tablet
                  This medicine is Beige, Round Tablet Imprinted With "1344".Beige Round 1344 - Ramelteon 8mg Tablet

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                  References

                  Best studies we found

                  TruPharma, LLC. (2023). Ramelteon tablet, film coated [package insert]. DailyMed.

                  You and Your Hormones. (2023). Prolactin.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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