Key takeaways
Ramelteon (Rozerem) and estazolam (Prosom) are both medications used to treat insomnia, but they have some key differences. Ramelteon is a melatonin receptor agonist that works like the natural hormone melatonin to help you fall asleep. It's not a controlled substance and isn't known to be habit-forming. On the other hand, Estazolam is a benzodiazepine that slows down brain activity to help you relax and stay asleep, but it's not a first-choice treatment for insomnia. It is a Schedule IV controlled substance, meaning it has a risk of misuse and dependence, and is only recommended for short-term use. Ramelteon is taken 30 minutes before bedtime on an empty stomach, while estazolam should be taken right before getting into bed. Ramelteon has fewer side effects, such as dizziness and sleepiness, whereas estazolam can cause more frequent side effects like sleepiness, headache, and weakness. Additionally, estazolam is not recommended for use in older adults due to the increased risk of falls.
