Key takeaways
Remeron (mirtazapine) and trazodone are both FDA approved for depression. But Remeron is more commonly used for depression than trazodone, which is more often used off-label for sleep. Mirtazapine is usually taken once daily at night because it can make you tired. Other side effects include weight gain, dry mouth, and dizziness. Trazodone is also usually taken once at night for sleep. It can also cause dry mouth and dizziness. Both medications can cause withdrawal symptoms if stopped suddenly, so it's important to follow your provider's instructions.
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