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Compare Trintellix vs. Pristiq

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Trintellix (vortioxetine)
    Desvenlafaxine (Pristiq)
  • Trintellix (vortioxetine)
    Desvenlafaxine (Pristiq)

  • Summary of Trintellix vs. Pristiq

    Summary for Atypical antidepressant
    Prescription only

    Trintellix (vortioxetine) belongs to a drug class known as atypical antidepressants. It's used to treat depression in adults. This medication is taken by mouth once a day. Some common side effects of Trintellix (vortioxetine) include nausea and diarrhea. It can also cause sexual problems, but not as much as some other antidepressants.

    Summary for SNRI
    Prescription only

    Desvenlafaxine (Pristiq) is a medication used to treat depression in adults. It's only available as a tablet that's typically taken once a day. This medication can raise your blood pressure, so it might not be the best choice if you have uncontrolled high blood pressure or heart problems.

  • Indications of Trintellix vs. Pristiq

    Indications for
    •Depression
    Indications for
    •Depression

  • Pros and Cons of Trintellix vs. Pristiq

    Pros and Const for Atypical antidepressant
    Pros
    •Can start to improve depression in as early as 2 weeks
    •Only needs to be taken once a day
    •Might be less likely to cause weight gain compared to other antidepressants
    Cons
    •Can take up to a month before you feel the full effects
    •Not available as a lower-cost generic
    •Not approved for use in children
    Pros and Const for SNRI
    Pros
    •A first-choice medication for treating depression in adults
    •Can take with or without food
    •Once-daily dosing makes it easier to remember to take
    •Lower-cost generic available
    •Less serious side effects compared to some other antidepressants
    Cons
    •Can take up to 8 weeks for effects to fully kick in
    •Can raise your blood pressure
    •Must lower dose slowly to stop the medication to avoid withdrawal symptoms
    •Not approved for use in children

  • Common Side Effects of Trintellix vs. Pristiq

    Common Side Effects for
    •Nausea (21-32%)
    •Diarrhea (7-10%)
    •Dizziness (6-9%)
    •Dry mouth (6-8%)
    •Vomiting (3-6%)
    •Constipation (3-6%)
    Common Side Effects for
    •Nausea (22%)
    •Dizziness (13%)
    •Dry mouth (11%)
    •Excessive sweating (10%)
    •Constipation (9%)
    •Trouble sleeping (9%)
    •Feeling tired (7%)
    •Loss of appetite (5%)
    •Sleepiness (4%)
    •Low sex drive (4%)

  • Warnings of Trintellix vs. Pristiq

    Common Side Effects for
    •Suicidal thoughts or behavior
    •Serotonin syndrome
    •Risk of bleeding
    •Not for use alone in bipolar disorder
    •Withdrawal symptoms
    •Low blood sodium levels
    •Glaucoma
    •Sexual problems
    Common Side Effects for
    •Suicidal thoughts and behaviors
    •Serotonin syndrome
    •High blood pressure
    •Higher bleeding risk
    •Worsening of glaucoma
    •Emergence of mania
    •Withdrawal symptoms
    •Seizures
    •Low sodium levels in the blood
    •Lung problems and pneumonia

  • Prices with our coupons for Trintellix vs. Pristiq

    Learn more about Trintellix
    Learn more about Desvenlafaxine

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