Key takeaways
Nefazodone (generic, formerly sold as Serzone) and Desvenlafaxine succinate ER (brand name Pristiq) are both used to treat depression, but they have some key differences. Nefazodone is an atypical antidepressant that increases serotonin and norepinephrine levels in the brain, while Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI). Nefazodone is taken twice daily and is only available as a generic, whereas Desvenlafaxine is taken once daily and is available as both a brand name and a generic. Nefazodone carries a serious risk of liver damage, making it a less preferred option, especially for those with liver issues. On the other hand, Desvenlafaxine can raise blood pressure and is not recommended for people with uncontrolled high blood pressure or heart problems. Both medications can take several weeks to show their full effects and have potential side effects, including the risk of worsening depression and suicidal thoughts, particularly in younger individuals.
