alprazolam
Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.
What is Alprazolam (Xanax)?
What is Alprazolam (Xanax) used for?
How Alprazolam (Xanax) works
Alprazolam (Xanax) is a fast-acting benzodiazepine. It relaxes your mood by affecting certain chemicals in the brain that are involved in feelings of anxiety.
Drug Facts
More on Alprazolam (Xanax) essentials
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What are the risks and warnings for Alprazolam (Xanax)?
Alprazolam (Xanax) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sedation and difficulty breathing
Risk factors: Taking alprazolam (Xanax) with opioids or alcohol | History of lung conditions
Some people with long-term pain might already be taking opioid medications. If this applies to you, let your care team know. The combination of alprazolam (Xanax) with opioid medication should be avoided because this raises the chance of overdose. Ask your care team if safer medication options are available. If you or a loved one notices that you're having trouble breathing or waking up easily, get medical help right away.
Potential for misuse, addiction, dependence, and withdrawal
Risk factors: Past substance misuse | Taking higher doses of alprazolam (Xanax) over a longer period of time | Stopping alprazolam (Xanax) suddenly
Additionally, taking alprazolam (Xanax) over longer periods of time can raise the risk for physical dependence. If so, suddenly stopping alprazolam (Xanax) can lead to withdrawal symptoms, including hallucinations, a change in behavior, and trouble sleeping. Sometimes, withdrawal symptoms can last weeks to years. Don't stop taking alprazolam (Xanax) without first talking to your HCP. Take alprazolam (Xanax) only as instructed to lower the risk of dependence and overdose.
Effect on driving and concentration
Risk factors: Drinking alcohol | Taking other medications that cause drowsiness
Alprazolam (Xanax) can make you feel sleepy and affect your concentration and focus. Drinking alcohol while taking alprazolam (Xanax) and taking additional medications that make you feel drowsy can make this effect worse. Avoid activities that require you to be alert, like driving or operating machinery, until you know how the medication affects you.
Harm to babies
Risk factors: Taking alprazolam (Xanax) while pregnant
Alprazolam (Xanax) can cause harm to your baby if you take the medication while you're pregnant. Newborn babies whose parent took alprazolam (Xanax) during pregnancy have experienced serious issues like breathing problems, excessive drowsiness, irritability, and feeding difficulties. If you're planning to have a baby or are currently pregnant, speak with your HCP about the best options for your anxiety or panic disorder.
Interactions with other medications
Alprazolam (Xanax) can interact with other medications. For example, certain medications can cause alprazolam (Xanax) to reach dangerously high levels in the body, which raises your risk for serious side effects. These include some antifungal medications, cimetidine (Tagamet HB), and some mental health medications like fluvoxamine (Luvox). Talk to your care team about all the medications you're taking or plan to take, including over-the-counter medications and supplements. They might need to make adjustments to the dose of certain medications or recommend safer alternatives.
Use with caution in people with depression
Risk factors: History of depression
Alprazolam (Xanax) can make depression worse. Sometimes, manic episodes have occurred when people with depression took alprazolam (Xanax). Watch for new or worsening signs of depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior while taking alprazolam (Xanax). Get medical help right away if you or a loved one notices any of these changes.
More on Alprazolam (Xanax) warnings
What are the side effects of Alprazolam (Xanax)?
Common Side Effects
- Drowsiness (41%)
- Lightheadedness (21%)
- Dry mouth (15%)
- Drowsiness (77%)
- Fatigue (49%)
- Poor coordination (40%)
- Memory issues (33%)
- Irritability (33%)
- Appetite changes (28-33%)
- Thinking problems (29%)
- Constipation (26%)
Other Side Effects
- Feeling confused
- Difficulty speaking (e.g., slurred speech)
- Weight changes
- Trouble urinating
- Change in sex drive
- Skin rash
Serious Side Effects
- Severe sedation: drowsiness, slowed breathing, confusion, memory problems, slurred speech, loss of consciousness
- Withdrawal symptoms: uncontrolled movements, blurred vision, trouble with sleep or memory, muscle pain and stiffness, anxiety, panic attacks, depression, irritability, hallucinations, convulsions or seizures, suicidal thoughts
Source:Â DailyMed
More on Alprazolam (Xanax) side effects
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Being forgetful
changes in patterns and rhythms of speech
clumsiness or unsteadiness
difficulty with coordination
discouragement
drowsiness
feeling sad or empty
irritability
lack of appetite
lightheadedness
loss of interest or pleasure
relaxed and calm
shakiness and unsteady walk
sleepiness
slurred speech
tiredness
trouble concentrating
trouble performing routine tasks
trouble sleeping
trouble speaking
unsteadiness, trembling, or other problems with muscle control or coordination
unusual tiredness or weakness
Less common
Blurred vision
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles, or tingling feelings
changes in behavior
chills
clay-colored stools
confusion about identity, place, and time
dark urine
decrease in frequency of urination
decrease in urine volume
difficult or labored breathing
difficulty in passing urine (dribbling)
difficulty with concentration
difficulty with moving
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
ear congestion
environment seems unreal
fainting
fear or nervousness
feeling of unreality
feeling warm
general feeling of discomfort or illness
headache
hyperventilation
inability to move the eyes
inability to sit still
increased blinking or spasms of the eyelid
irregular heartbeats
itching or rash
joint pain
lack or loss of self-control
loss of bladder control
loss of coordination
loss of memory
loss of voice
mood or mental changes
muscle aches, cramps, pain, stiffness, or weakness
need to keep moving
problems with memory
restlessness
runny or stuffy nose
seeing, hearing, or feeling things that are not there
seizures
sense of detachment from self or body
shaking
shivering
sticking out of the tongue
stomach pain
sweating
swollen joints
talkativeness
tightness in the chest
trouble with balance
twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
uncontrolled twisting movements of the neck, trunk, arms, or legs
unpleasant breath odor
unusual dullness or feeling of sluggishness
unusual facial expressions
unusually deep sleep
unusually long duration of sleep
vomiting of blood
yellow eyes or skin
Rare
Actions that are out of control
attack, assault, or force
continuing ringing or buzzing or other unexplained noise in the ears
decreased awareness or responsiveness
deep or fast breathing with dizziness
ear pain
false or unusual sense of well-being
fast, irregular, pounding, or racing heartbeat or pulse
feeling jittery
feeling unusually cold
generalized slowing of mental and physical activity
hearing loss
hoarseness
lack of feeling or emotion
loss of control of the legs
loss of strength or energy
nightmares
numbness of the feet, hands, and around mouth
severe sleepiness
shakiness in the legs, arms, hands, or feet
sleep talking
swelling
talking, feeling, and acting with excitement
thoughts of killing oneself
uncaring
unusual weak feeling
voice changes
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Confusion
loss of consciousness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Absent, missed, or irregular menstrual periods
decreased appetite
decreased interest in sexual intercourse
decreased sexual performance or desire abnormal ejaculation
difficulty having a bowel movement (stool)
inability to have or keep an erection
increased appetite
increased in sexual ability, desire, drive, or performance
increased interest in sexual intercourse
increased weight
loss in sexual ability, desire, drive, or performance
stopping of menstrual bleeding
watering of the mouth
Less common
Blistering, crusting, irritation, itching, or reddening of the skin
change in taste bad unusual or unpleasant (after) taste
cracked, dry, or scaly skin
double vision
feeling of warmth
menstrual changes
pelvic pain
redness of the face, neck, arms, and occasionally, upper chest
seeing double
stomach bloating and cramping
sudden sweating
unexplained runny nose or sneezing
Rare
Acid or sour stomach
belching
bigger, dilated, or enlarged pupils (black part of the eye)
change in color vision
difficulty seeing at night
feeling of constant movement of self or surroundings
feeling of relaxation
hives or welts
increased sensitivity of the eyes to sunlight
indigestion
redness of the skin
sensation of spinning
stomach discomfort or upset
Incidence not known
Blistering, peeling, or loosening of the skin
red, irritated eyes
red skin lesions, often with a purple center
sores, ulcers, or white spots in the mouth or on the lips
swelling of the breasts or breast soreness in both females and males
unexpected or excess milk flow from the breasts
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Alprazolam (Xanax)
Pros
Taken by mouth
Can start to work in 30 minutes
Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills
Cons
Can cause memory problems, drowsiness, and confusion
Stopping suddenly can cause withdrawal symptoms
Not preferred during pregnancy
Pharmacist tips for Alprazolam (Xanax)
Take alprazolam (Xanax) as prescribed by your healthcare professional (HCP) to lower your risk of overdose or dependence. Don't stop taking this medication without first talking to your HCP.
If you've taken alprazolam (Xanax) for a while and want to stop the medication, your HCP can work with you to do so by slowly lowering your dose to prevent withdrawal symptoms like anxiety, depression, blurred vision, nausea, vomiting, and seizures.
Avoid taking alprazolam (Xanax) with opioid pain medications because this combination can be life-threatening.
Alprazolam (Xanax) can cause dizziness and drowsiness. Avoid activities that require you to be alert (like driving) until you know how this medication affects you.
Avoid drinking alcohol while you're taking alprazolam (Xanax). This combination can lead to serious side effects, such as confusion and trouble breathing.
For the oral solution:
Make sure to use the dropper that comes with your prescription to draw up your dose. Don't use household spoons to measure alprazolam (Xanax), since this could cause you to take the wrong dose.
After you've opened the bottle of oral solution, throw it away after 90 days because it might not work as well after that time.
For the orally disintegrating tablets:
Use dry hands to remove the tablets from the bottle. Moisture can cause the tablets to break down, which means you might not get your full dose. Keep the bottle tightly closed when you're not using it to prevent moisture from affecting the tablets.
To take the medication, place the tablet on top of your tongue, and let it dissolve. Then, swallow with your saliva. You don't need to drink any liquid with it.
Frequently asked questions about Alprazolam (Xanax)
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Alprazolam (Xanax) dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 30ml of 1mg/ml | 1 bottle | $92.94 | $92.94 |
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 10 orally disintegrating tablets of 0.25mg | 3 dose packs | $17.25 | $5.75 |
| 10 orally disintegrating tablets of 0.5mg | 3 dose packs | $26.85 | $8.95 |
| 10 orally disintegrating tablets of 1mg | 3 dose packs | $32.06 | $10.69 |
| 10 orally disintegrating tablets of 2mg | 9 dose packs | $96.27 | $10.70 |
Typical dosing for Alprazolam (Xanax)
Immediate-release tablets, orally disintegrating tablets, and oral solution:
Generalized anxiety disorder: The typical starting dose is 0.25 mg to 0.5 mg by mouth three times a day.
Panic disorder: The typical starting dose is 0.5 mg by mouth three times a day.
Your dose might differ if you're 65 years or older, or have liver problems. Your healthcare professional (HCP) might also change your dose based on how you respond to the medication.
Alprazolam (Xanax) Reviews
GoodRx has partnered with PatientsLikeMe to provide reviews on the different aspects of Alprazolam (Xanax).
Effectiveness
Learn more about the effectiveness of Alprazolam (Xanax) based on real life experiences.
Overall Rating
Based on 349 people taking this medication
3.8
Effectiveness by condition:
panic disorder230 reviews
3.9
generalized anxiety disorder69 reviews
4.1
post-traumatic stress disorder23 reviews
3.8
bipolar disorder16 reviews
2.6
social anxiety disorder11 reviews
4.4
Severity of side effects
Based on 1271 people taking this medication
0%
50%
100%
Top side effects
Sleepiness
9%
Drowsiness
8%
Sedation
5%
Problems concentrating
3%
Memory problems
3%
Reasons people stopped taking Alprazolam (Xanax)
Based on 1095 people who have taken this medication
Doctor's advice
28%
Other
24%
Did not seem to work
18%
Side effects too severe
12%
Course of treatment ended
11%
Personal research
5%
Change in health plan coverage
3%
Expense
3%
Interactions between Alprazolam (Xanax) and other drugs
More on Alprazolam (Xanax) interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Boceprevir
- Clarithromycin
- Cobicistat
- Conivaptan
- Flumazenil
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir
- Nefazodone
- Nelfinavir
- Posaconazole
- Saquinavir
- Telaprevir
- Telithromycin
- Voriconazole
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Acepromazine
- Alfentanil
- Amiodarone
- Amobarbital
- Amprenavir
- Anileridine
- Aprepitant
- Aripiprazole
- Aripiprazole Lauroxil
- Asenapine
- Atazanavir
- Baclofen
- Benperidol
- Benzhydrocodone
- Bromazepam
- Bromopride
- Buprenorphine
- Buspirone
- Butabarbital
- Butalbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Carbamazepine
- Carbinoxamine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chlorpromazine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Clobazam
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Dantrolene
- Darunavir
- Dasabuvir
- Delavirdine
- Dexmedetomidine
- Diacetylmorphine
- Diazepam
- Dichloralphenazone
- Difenoxin
- Digoxin
- Dihydrocodeine
- Diltiazem
- Diphenhydramine
- Diphenoxylate
- Domperidone
- Doxylamine
- Dronedarone
- Droperidol
- Elagolix
- Enflurane
- Erythromycin
- Esketamine
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Fentanyl
- Flibanserin
- Fluconazole
- Flunitrazepam
- Fluphenazine
- Flurazepam
- Fluspirilene
- Fluvoxamine
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Fospropofol
- Gabapentin
- Gabapentin Enacarbil
- Halazepam
- Halothane
- Hexobarbital
- Hydrocodone
- Hydromorphone
- Hydroxyzine
- Imatinib
- Isoflurane
- Ivacaftor
- Ketamine
- Ketazolam
- Ketobemidone
- Larotrectinib
- Lemborexant
- Letermovir
- Levocetirizine
- Levorphanol
- Lofexidine
- Lomitapide
- Lorazepam
- Loxapine
- Magnesium Oxybate
- Meclizine
- Melperone
- Meperidine
- Mephenesin
- Mephobarbital
- Meprobamate
- Meptazinol
- Mesoridazine
- Metaxalone
- Methadone
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metoclopramide
- Mibefradil
- Midazolam
- Mifepristone
- Mirtazapine
- Molindone
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Nalbuphine
- Netupitant
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Olanzapine
- Opium
- Opium Alkaloids
- Orphenadrine
- Oxazepam
- Oxycodone
- Oxymorphone
- Palbociclib
- Papaveretum
- Paregoric
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenobarbital
- Pimozide
- Piperacetazine
- Piperaquine
- Pipotiazine
- Piritramide
- Potassium Oxybate
- Prazepam
- Pregabalin
- Primidone
- Prochlorperazine
- Promazine
- Promethazine
- Propofol
- Quazepam
- Quetiapine
- Ramelteon
- Ranitidine
- Ranolazine
- Remifentanil
- Remimazolam
- Remoxipride
- Ritonavir
- Scopolamine
- Secobarbital
- Sertindole
- Sodium Oxybate
- Sufentanil
- Sulpiride
- Suvorexant
- Tapentadol
- Temazepam
- Thiethylperazine
- Thiopental
- Thiopropazate
- Thioridazine
- Tilidine
- Tizanidine
- Tolonium Chloride
- Topiramate
- Tramadol
- Trazodone
- Triazolam
- Trifluoperazine
- Trifluperidol
- Triflupromazine
- Trimeprazine
- Verapamil
- Voxelotor
- Zaleplon
- Zolpidem
- Zopiclone
- Zotepine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Fluoxetine
- Kava
- Rifapentine
- Roxithromycin
- Sertraline
- St John's Wort
- Theophylline
- Troleandomycin
How much does Alprazolam (Xanax) cost?
Alprazolam (Xanax) contraindications
Taking with medications considered as strong CYP3A inhibitors, except ritonavir (Norvir)
What are alternatives to Alprazolam (Xanax)?
Depression in people ages 12 years and older
Generalized anxiety disorder (GAD) in people ages 7 years and older
What is the latest news about Alprazolam (Xanax)?
Alprazolam (Xanax) images
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References
Best studies we foundActavis Pharma, Inc. (2022). Alprazolam tablet, orally disintegrating [package insert]. DailyMed.
Actavis Pharma, Inc. (2023). Alprazolam tablet [package insert]. DailyMed.
Armstrong, C. (2008). ACOG guidelines on psychiatric medication use during pregnancy and lactation. American Family Physician.
Balon, R., et al. (2009). Medications and sexual function and dysfunction. Focus.
George, T. T., et al. (2023). Alprazolam. StatPearls.
Hikma Pharmaceuticals USA Inc. (2023). Alprazolam solution, concentrate [package insert]. DailyMed.
McElhatton, P. R. (1994). The effects of benzodiazepine use during pregnancy and lactation. Reproductive Toxicology.
PatientsLikeMe. (n.d.). What is alprazolam?
U.S. Food and Drug Administration. (2023). Drug development and drug interactions | Table of substrates, inhibitors and inducers.
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