Key takeaways
Lexapro (escitalopram) and nefazodone are both used to treat depression, but they have some key differences. Lexapro is a selective serotonin reuptake inhibitor (SSRI) and is also approved for generalized anxiety disorder (GAD). It is a first-choice option for both conditions and is available in both tablet and liquid forms. Nefazodone, on the other hand, is an atypical antidepressant that affects both serotonin and norepinephrine levels. It is not a first-choice option due to its risk of serious liver damage. Lexapro is typically taken once daily, while nefazodone needs to be taken twice daily. Lexapro can cause side effects like nausea and trouble sleeping, whereas nefazodone can cause headaches, dry mouth, and dizziness. Both medications can cause withdrawal symptoms if stopped abruptly.
