Key takeaways
Nefazodone (generic only) and sertraline (Zoloft) are both used to treat depression, but they belong to different medication classes. Nefazodone is an atypical antidepressant that increases serotonin and norepinephrine levels, while Zoloft is a selective serotonin reuptake inhibitor (SSRI) that specifically raises serotonin levels. Nefazodone is taken twice daily and has a serious risk of liver damage, making it less commonly prescribed. In contrast, Zoloft is taken once daily and is also approved for various anxiety disorders, including OCD and PTSD. Zoloft can cause weight gain and withdrawal symptoms if stopped abruptly, whereas nefazodone is not typically associated with weight changes but can still cause withdrawal symptoms. Both medications can worsen depression and increase suicidal thoughts, especially in younger people.
