Key takeaways
Venlafaxine (Effexor) and nefazodone (Serzone) are both used to treat depression, but they have some key differences. Venlafaxine (Effexor) is a serotonin and norepinephrine reuptake inhibitor (SNRI) that also treats anxiety, social anxiety disorder, and panic disorder. Nefazodone, on the other hand, is an atypical antidepressant that is usually not a first-choice option because it can cause serious liver damage. Venlafaxine (Effexor) is available in both immediate-release and extended-release forms, while nefazodone is only available as a generic medication since the brand name Serzone has been discontinued. Venlafaxine (Effexor) can cause severe withdrawal symptoms if stopped suddenly, whereas withdrawal symptoms are less common with nefazodone. Additionally, venlafaxine (Effexor) may raise blood pressure and has a higher risk of causing serotonin syndrome when taken with other medications that affect serotonin levels. Nefazodone, however, has a significant risk of liver failure and interacts with many medications, making it less commonly prescribed.
