Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Venlafaxine (Effexor) and pregabalin (Lyrica) are both prescription medications, but they are used for different conditions and belong to different drug classes. Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, social anxiety disorder, and panic disorder. It works by increasing serotonin and norepinephrine levels in the brain. Pregabalin, on the other hand, is an anticonvulsant used to treat nerve pain from diabetes, shingles, spinal cord injury, fibromyalgia, and partial-onset seizures. It is thought to lower certain chemicals in the brain to relieve pain and prevent seizures. Venlafaxine is available as a lower-cost generic, while pregabalin is also available in a generic form. Venlafaxine can cause withdrawal symptoms if stopped suddenly, while pregabalin can lead to dizziness, drowsiness, and weight gain. Additionally, pregabalin is a Schedule V controlled substance due to its potential for addiction and dependence, whereas venlafaxine is not a controlled medication.
Venlafaxine
Pregabalin (Lyrica)
Venlafaxine
Pregabalin (Lyrica)
Summary of Effexor XR vs. Lyrica
Summary for SNRI
Prescription only
Venlafaxine is an antidepressant used to treat mental health conditions like depression, generalized anxiety disorder, social anxiety disorder, and panic disorder. It comes in two forms: extended-release, which is taken once a day, and immediate-release, which is taken in split doses throughout the day. This medication can interact with many things, including other medications and alcohol. Possible side effects can include nausea, weight changes, and sexual problems. It can also cause withdrawal symptoms if you stop taking it suddenly.
Summary for Antiepileptic
Prescription only
Pregabalin (Lyrica) helps treat nerve pain and fibromyalgia in adults. It can also be taken with other medications to help treat certain seizures in people 1 month and older. Pregabalin (Lyrica) comes as a capsule and oral solution in both brand-name and generic versions. The dosage depends on what condition you're treating, but it's usually taken by mouth 2 or 3 times a day. Common side effects include feeling dizzy and drowsy. This medication is a controlled substance and has interactions, like with alcohol and benzodiazepines.