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Cymbalta vs. Luvox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cymbalta (duloxetine) and fluvoxamine are both prescription medications, but they belong to different drug classes and treat different conditions. Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor) used to treat depression, anxiety, and various types of long-term pain, including diabetic neuropathy and fibromyalgia. On the other hand, fluvoxamine is an SSRI (selective serotonin reuptake inhibitor) primarily used to treat obsessive-compulsive disorder (OCD) in adults and children aged 8 years and older. Cymbalta is typically taken once daily, while fluvoxamine can be taken once or twice daily depending on the form and dose. Both medications can cause side effects like nausea and headache, but fluvoxamine is more likely to cause sleep problems and has a higher risk of drug interactions. Additionally, Cymbalta can be taken at any time of day, whereas fluvoxamine is often taken at bedtime to help manage drowsiness. Both medications are available in generic forms, making them more affordable options.

Duloxetine

(Cymbalta)

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Fluvoxamine

 

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Summary for Cymbalta

Prescription only

Duloxetine (Cymbalta) helps treat depression and anxiety. It can also help with some types of chronic pain, such as nerve pain from diabetes. Duloxetine (Cymbalta) is a type of antidepressant called an SNRI, or serotonin and norepinephrine reuptake inhibitor. Most people take it by mouth once a day, but some with depression might take it twice a day. Side effects include nausea, headache, and dry mouth. When it's time to stop taking the medication, the prescriber will slowly lower your dose to help prevent withdrawal symptoms.

Indications for Cymbalta

Pros and Cons for Cymbalta

Pros

  • Taken once a day for most people
  • Can take at any time of day
  • A first-choice option for depression
  • An option for some types of chronic pain, like nerve pain from diabetes

Cons

  • Can take several weeks before you feel its full effects
  • Might not be a good option for people who drink heavily or have liver or kidney problems
  • Can cause nausea or dry mouth
  • Can interact with many medications, including other antidepressants and certain pain relievers

Common Side Effects for Cymbalta

  • Nausea (23%)
  • Headache (14%)
  • Dry mouth (13%)
  • Drowsiness (10%)
  • Feeling tired (9%)
  • Trouble sleeping (9%)
  • Dizziness (9%)
  • Constipation (9%)
  • Diarrhea (9%)
  • Low appetite (7%)
  • A lot of sweating (6%)
  • Stomach pain (5%)

Warnings for Cymbalta

  • Suicidal thoughts or behavior
  • Liver damage
  • Changes in blood pressure and risk of falls
  • Serotonin syndrome
  • Higher risk of bleeding
  • Severe skin reaction
  • Withdrawal symptoms
  • Low sodium levels
  • Sexual problems
  • Not for use alone for bipolar disorder because of the risk of mania
  • Angle-closure glaucoma in certain people

Summary for Luvox

Prescription only

Fluvoxamine maleate is an SSRI, or a selective serotonin reuptake inhibitor. It's approved to treat obsessive-compulsive disorder (OCD) in people ages 8 years and up. Fluvoxamine comes as immediate-release tablets taken by mouth once or twice a day. For adults, it also comes as extended-release capsules taken once a day. Your specific dosage depends on which form you're taking. Side effects include nausea, sleepiness or trouble sleeping, and headache. Fluvoxamine is a generic medication; the brand name Luvox is no longer available.

Indications for Luvox

Pros and Cons for Luvox

Pros

  • A first-choice treatment option for OCD
  • Immediate-release tablets approved for children as young as 8 years old

Cons

  • Can cause a lot of side effects, like sleepiness, nausea, diarrhea, and dry mouth
  • Can interact with many medications, such as triptan migraine medications, antidepressants, and benzodiazepines

Common Side Effects for Luvox

Immediate-release tablets:

  • Nausea (40%)
  • Headache (22%)
  • Sleepiness (22%)
  • Trouble sleeping (21%)
  • Dry mouth (14%)
  • Weakness (14%)
  • Nervousness (12%)
  • Dizziness (11%)
  • Diarrhea (11%)
  • Constipation (10%)
  • Indigestion (10%)

Extended-release capsules:

  • Trouble sleeping (35%)
  • Nausea (34%)
  • Headache (32%)
  • Sleepiness (27%)
  • Weakness (26%)
  • Diarrhea (18%)
  • Low appetite (13%)
  • Dizziness (12%)
  • General pain (10%)
  • Dry mouth (10%)
  • Low sex drive or ejaculation problems (10%)

Warnings for Luvox

  • Risk of suicidal thoughts and behavior
  • Serotonin syndrome
  • Dangerous drug interactions
  • Withdrawal symptoms
  • Higher risk of bleeding
  • Low sodium levels
  • Sexual problems
  • Not for use alone for bipolar disorder because of the risk of mania
  • Angle-closure glaucoma in certain people

Prices with our coupons for Cymbalta vs. Luvox

Price Card Drug Icon
Duloxetine30 capsules / 60mg
$11.45$32.26
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Fluvoxamine90 tablets / 100mg
$36.00$121.19
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