Key takeaways
Lyrica (Pregabalin) and Depakote (Divalproex) are both antiepileptic medications, but they have different uses and side effects. Pregabalin is used to treat nerve pain from conditions like diabetes, shingles, and spinal cord injuries, as well as fibromyalgia and partial-onset seizures. It is available in capsule and oral solution forms and is typically taken 2 or 3 times a day. Common side effects include dizziness and drowsiness. Depakote, on the other hand, is used to treat seizures, prevent migraines, and manage bipolar disorder. It comes in delayed-release and extended-release tablets, as well as sprinkle capsules, and is usually taken once or twice daily. Divalproex can cause nausea, sleepiness, and weight changes. Unlike pregabalin, divalproex is not a controlled substance but requires regular blood tests to monitor liver health. Both medications have generic versions available, making them more affordable.
