Key takeaways
Nortriptyline (Pamelor) and desipramine (Norpramin) are both tricyclic antidepressants (TCAs) used to treat depression, but they have some differences. Nortriptyline is available in both capsule and liquid forms, while desipramine only comes in tablet form. Nortriptyline is typically taken three to four times a day, whereas desipramine is usually taken once daily. Nortriptyline may take 6 to 8 weeks to show full effects, while desipramine might start working within 2 to 3 weeks. Both medications can cause side effects like dry mouth, nausea, and dizziness, but desipramine is more likely to cause weight gain. Nortriptyline is noted for having fewer side effects compared to other TCAs, while desipramine is not a first-choice treatment due to its side effects. Both medications carry risks of suicidal thoughts, especially in younger individuals, and should not be stopped suddenly without consulting a healthcare provider.
