provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Divalproex Coupon - Divalproex 500mg tablet

divalproex

Generic Depakote
Used for Migraine, Bipolar Disorder, Epilepsy
Used for Migraine, Bipolar Disorder, Epilepsy

Divalproex (Depakote) is a prescription medication that's used alone or in combination with other medications to treat certain types of seizures. It can also be used to prevent migraines and treat bipolar disorder. Divalproex (Depakote) comes in delayed-release (DR) and extended-release (ER) tablets, as well as sprinkle capsules. You take it by mouth, typically once or twice daily, depending on the formulation. Divalproex (Depakote) can cause changes in weight, both in weight loss and weight gain. Don't suddenly stop taking this medication since it can raise your risk of withdrawal symptoms, including seizures.

Last reviewed on July 12, 2023
basics-icon

What is Divalproex (Depakote)?

What is Divalproex (Depakote) used for?

  • Bipolar disorder

  • Seizures (focal impaired awareness seizure, absence seizure)

  • Migraine prevention

How Divalproex (Depakote) works

Divalproex (Depakote) is an antiepileptic. It's not exactly clear how this medication works to prevent migraines or treat mania episodes in bipolar. But in order to control seizures, divalproex (Depakote) signals your brain to make more of a chemical called gamma-aminobutyric acid (GABA). GABA helps to reduce the bursts of activity in your brain, which prevents seizures.

Are you looking for information on valproic acid instead?
When does Divalproex (Depakote) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsDepakote, Depakote ER, Depakote Sprinkles
Drug ClassAntiepileptic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Divalproex (Depakote) essentials

coupon-save-icon

Get your GoodRx coupon

Avg retail price
$99.94(save 87.99%)
GoodRx discount
$12.00
See prices
basics-icon

What are the side effects of Divalproex (Depakote)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Bipolar disorder
  • Nausea (22%)
  • Excess sleepiness (19%)
  • Dizziness (12%)
  • Vomiting (12%)
  • Accidental injury (11%)
  • Low energy (10%)
Seizures
  • Nausea (48%)
  • Headache (31%)
  • Feeling weak (27%)
  • Vomiting (27%)
  • Tremor (25%)
  • Dizziness (25%)
  • Stomach pain (23%)
Migraine
  • Nausea (31%)
  • Feeling weak (20%)
  • Excessive sleepiness (17%)
  • Indigestion (13%)
  • Diarrhea (12%)
  • Dizziness (12%)
  • Vomiting (11%)

Other Side Effects

  • Double or blurry vision
  • Diarrhea
  • Changes in appetite
  • Body aches, cough, and other flu-like symptoms
  • Rash
  • Fever
  • Constipation
  • Movements problems
  • Feeling more emotional
  • Trouble remembering
  • Hair loss
  • Weight loss
  • Back pain
Please note: The side effects listed were reported by people who took delayed-release divalproex (Depakote) in clinical studies.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Suicidal thoughts or behaviors
  • Severe allergic reactions: fever, rash, extreme tiredness, body aches, mouth sores, blisters, trouble breathing
  • Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
  • Extremely high blood ammonia levels: fatigue, poor mental alertness, vomiting
  • Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
  • Serious bleeds: bleeding that's difficult to stop, vomiting blood, blood in the urine or stool, "coffee-ground" stool
  • Extreme drop in body temperature: shivering, feeling tired, feeling confused, slurred speech, coma
When do Divalproex (Depakote) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Nausea / vomiting
Stomach pain / indigestion
Diarrhea
Tremor
Suicidal thoughts and behavior
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

chills

confusion

cough

crying

delusions of persecution, mistrust, suspiciousness, or combativeness

diarrhea

difficult or labored breathing

dysphoria

false beliefs that cannot be changed by facts

false or unusual sense of well-being

feeling of unreality

fever

general feeling of discomfort or illness

headache

hoarseness

joint pain

loss of appetite

lower back or side pain

mental depression

muscle aches and pains

nausea

nervousness

painful or difficult urination

pinpoint red spots on the skin

poor insight and judgment

problems with memory or speech

quick to react or overreact emotionally

rapid weight gain

rapidly changing moods

runny nose

sense of detachment from self or body

shakiness in the legs, arms, hands, or feet

shivering

sleepiness or unusual drowsiness

sore throat

sweating

tightness in the chest

tingling of the hands or feet

trembling or shaking of the hands or feet

trouble recognizing objects

trouble sleeping

trouble thinking and planning

trouble walking

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

vomiting

Less common

Abnormal dreams

absence of or decrease in body movement

anxiety

bloody nose

blurred vision

bruising burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in personality

change in walking and balance

changes in patterns and rhythms of speech

chest pain

cloudy urine

clumsiness or unsteadiness

cold sweats

constipation

dark urine

deep or fast breathing with dizziness

degenerative disease of the joint

difficulty with moving

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

excessive muscle tone

fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth or heat

flushing or redness of the skin, especially on the face and neck

frequent urge to urinate

heavy non-menstrual vaginal bleeding

increased need to urinate

indigestion

lack of coordination

large, flat, blue or purplish patches in the skin

leg cramps

lip smacking or puckering

loss of bladder control

loss of strength or energy

multiple swollen and inflamed skin lesions

muscle pain or stiffness

muscle tension or tightness

normal menstrual bleeding occurring earlier, possibly lasting longer than expected

numbness of the feet, hands and around mouth

pains in the stomach, side, or abdomen, possibly radiating to the back

passing urine more often

pounding in the ears

puffing of the cheeks

rapid or worm-like movements of the tongue

rapid weight gain

restlessness

seeing, hearing, or feeling things that are not there

shakiness and unsteady walk

slurred speech

small red or purple spots on the skin

sweating

swollen joints

trouble with speaking

twitching

uncontrolled chewing movements

uncontrolled movements of the arms and legs

unsteadiness, trembling, or other problems with muscle control or coordination

vomiting of blood or material that looks like coffee grounds

yellow eyes or skin

Incidence not known

Aggression

bladder pain

blistering, peeling, loosening of the skin

blisters on the skin

bone pain, tenderness, or aching

chest discomfort

cloudy urine

decrease in height

decreased urine output

difficulty swallowing

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

hives, itching, skin rash

increased sensitivity of the skin to sunlight

increased thirst

irritability

joint or muscle pain

loss of balance control

loss of consciousness

mask-like face

pain in the back, ribs, arms, or legs

pain or swelling in the arms or legs without any injury

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

redness or other discoloration of the skin

seizures

severe mood or mental changes

severe sunburn

shuffling walk

slow heartbeat

slowed movements

slurred speech

sores, ulcers, or white spots in the mouth or on the lips

stiffness of the arms and legs

swelling of the face, ankles, or hands

swollen or painful glands

tic-like (jerky) movements of the head, face, mouth, and neck

unusual behavior

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

fainting

loss of consciousness

slow or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Belching

body aches or pain

change in vision

congestion

continuing ringing or buzzing or other unexplained noise in the ears

hair loss or thinning of the hair

hearing loss

heartburn

impaired vision

lack or loss of strength

loss of memory

problems with memory

seeing double

tender, swollen glands in the neck

uncontrolled eye movements

voice changes

weight gain

weight loss

Less common

Absent, missed, or irregular menstrual periods

burning, dry, or itching eyes

change in taste or bad unusual or unpleasant (after) taste

coin-shaped lesions on the skin

cough producing mucus

cramps

dandruff

discharge or excessive tearing

dry skin

earache

excess air or gas in the stomach or bowels

eye pain

feeling of constant movement of self or surroundings

full feeling

heavy bleeding

increased appetite

itching of the vagina or genital area

loss of bowel control

neck pain

oily skin

pain

pain during sexual intercourse

pain or tenderness around the eyes and cheekbones

passing gas

rash with flat lesions or small raised lesions on the skin

redness or swelling in the ear

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

redness, swelling, or soreness of the tongue

sensation of spinning

sneezing

stiff neck

stopping of menstrual bleeding

thick, white vaginal discharge with no odor or with a mild odor

Incidence not known

Breast enlargement

changes in hair color or texture

discoloration of the fingernails or toenails

increased hair growth, especially on the face

unexpected or excess milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Divalproex (Depakote)

thumbs-up

Pros

Available as a lower-cost generic

Dose can be adjusted based on your response

Available in various forms: delayed-release tablets, sprinkle capsules, and extended-release tablets

Can be used on its own or with other medications to control seizures

thumbs-down

Cons

Can prevent migraines from happening, but it won't help if you have a migraine attack

Interacts with many medications, such as phenytoin (Dilantin)

Can’t take while pregnant

Requires regular blood work and lab tests to make sure your liver is healthy

pharmacist-tips

Pharmacist tips for Divalproex (Depakote)

pharmacist
  • Different formulations of divalproex (Depakote) might have different directions and age-cut offs. If you (or your child) are just starting or switching to a different formulation of divalproex (Depakote), double check with your provider that the formulation, dose, and directions are appropriate.

    • If you want to stop treatment with divalproex (Depakote), talk with your provider. Don't stop taking divalproex (Depakote) suddenly, especially if you've a history of seizures. Doing so can raise your risk for seizures that won't stop. Your provider can help you stop this medication safely by lowering your dose slowly over time.

      • Your provider might ask you to get blood tests done routinely while you’re taking divalproex (Depakote). This is so that they can watch out for your liver health. Tell your provider right away if you've symptoms of liver damage, such as feeling sleepy, upper right stomach pain, yellowing of the skin or eyes, or dark urine.

        • In some rare cases, divalproex (Depakote) can cause high blood ammonia levels. Let your provider know if you experience symptoms of fatigue, poor mental alertness, or vomiting.

          • If you're able to become pregnant, make sure to use birth control, like condoms, while taking divalproex (Depakote). Don't take divalproex (Depakote) if you're pregnant since it can cause harm to the unborn baby. If you're pregnant or thinking of getting pregnant during treatment, contact your provider right away. Your provider might prescribe you a different medication that's safer during pregnancy.

            • Let your provider know if you experience symptoms of depression or worsening mood while taking divalproex (Depakote).

              • Divalproex (Depakote) can sometimes cause rash and other severe skin reactions. If you have a rash, skin pain, blisters, or skin peeling, talk with your provider right away.

                • Avoid drinking alcohol while taking divalproex (Depakote) because it can worsen some of the side effects such as sleepiness and dizziness. In particular, divalproex (Depakote) can cause extreme drowsiness in people over 65 years old, which can raise the risk of falling. Tell your provider if you're experiencing more drowsiness than usual. Your provider might start you at a lower dose of this medication.

                  • If you notice what looks like a pill in your stool, contact your provider. This could be a sign your body isn't absorbing divalproex (Depakote) correctly.

                    • Directions for divalproex (Depakote) sprinkle capsules: If you have trouble swallowing, you can open up the capsule and sprinkle the content on soft food, such as applesauce or yogurt. Make sure to hold the capsule so the end marked "This end up" is upright. Twist open the capsule over soft food to prevent spilling. Take the entire mixture immediately after mixing. Avoid chewing the mixture since this can change how the medication gets absorbed. Rinse down the content with water to help make sure all of the medication is swallowed.

                      faqs

                      Frequently asked questions about Divalproex (Depakote)

                      How does taking divalproex (Depakote) make you feel?
                      When you first start taking divalproex (Depakote), you might experience some side effects, such as nausea, vomiting, sleepiness, and weakness. To lower your risk of these side effects, your provider will have you start with a lower dose of divalproex (Depakote) and raise the dose slowly over time to better control your symptoms. It's best to avoid driving or doing activities that need a lot of focus until you know how this medication makes you feel. If the side effects are making it difficult for you to get through the day, let your provider know. Depending on what you experience, they might give you tips to manage the side effects, adjust your dose of divalproex (Depakote), or consider other medication options for you.
                      Is divalproex (Depakote) an antipsychotic?
                      No, divalproex (Depakote) isn't an antipsychotic; it's an antiepileptic. Medications in both these classes can treat bipolar disorder. If you're taking divalproex (Depakote) for bipolar disorder, your provider might prescribe antipsychotic medications to help with your symptoms. Talk with your provider if you've questions about your medications.
                      Is valproic acid the same as divalproex (Depakote)?
                      Divalproex (Depakote) and valproic acid are both antiepileptics used to treat certain types of seizures. They're both available by prescription from your provider; both have lower-cost generics available as well. Both medications have similar chemical structures, so you shouldn't take both at the same time. In fact, divalproex (Depakote) gets broken down in your body to valproic acid. The American Academy of Neurology doesn't recommend one over another when it comes to controlling partial or absence seizures.
                      Does divalproex (Depakote) cause weight gain?
                      In clinical studies, people who took divalproex (Depakote) reported both weight gain and weight loss. Typically, people who took higher doses of divalproex (Depakote) were more likely to gain weight. And older adults were more likely to experience weight loss from divalproex (Depakote). One thing to keep in mind is that weight loss can be a symptom of other side effects of divalproex (Depakote) that might require more medical attention, including liver and pancreas problems. Talk with your provider if you're concerned about divalproex (Depakote) and weight changes. They might recommend that you keep a record of your weight so you can spot any patterns or trends.
                      Does divalproex (Depakote) make you sleepy?
                      Yes, taking divalproex (Depakote) can make you feel sleepy, weak, or excessively drowsy. These side effects can be worse for older adults. To be safe, don't drive a car, operate machinery, or do anything that requires a lot of focus until you know how this medication affects you. You shouldn't take divalproex (Depakote) with alcohol because doing so can make you feel more sleepy and dizzy. If you're over 65 years old, talk to your provider to see if divalproex (Depakote) is a safe treatment option for you.
                      How long does divalproex (Depakote) stay in your system?
                      It can take between 2 to 4 days for most of divalproex (Depakote) to leave your body. Keep in mind that this time frame is estimated based on the half-life of divalproex (Depakote). It can also be affected by your health conditions and genetics, so it can be different for each individual person. If you're experiencing side effects from this medication, talk with your provider right away. Don't stop taking divalproex (Depakote) suddenly since it can cause your seizures to come back or become worse. Your provider will work with you to lower your dose slowly over time so this doesn't happen.
                      GoodRxEducationalIcon

                      How to save using GoodRx

                      Compare Prices
                      1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                      Select your free coupon
                      2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                      Show coupon to your pharmacist
                      3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                      Get free couponLearn more
                      warings-icon

                      What are the risks and warnings for Divalproex (Depakote)?

                      Divalproex (Depakote) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Liver problems

                      • Risk factors: Children under 2 years old | Taking multiple anti-seizure medications | Severe seizure problems | Certain genetic metabolic problems | Current or history of liver problems

                        Divalproex (Depakote) can cause liver problems that can be life-threatening. These problems are more common in the first 6 months of treatment. Your risk is higher if you've a history of liver problems. If you've any of the risk factors listed above, please talk with your provider so they can decide whether divalproex (Depakote) is a safe treatment for you.

                        Your provider will order blood tests before you start and while you're taking divalproex (Depakote) to check your liver health. If you experience symptoms of liver problems, such as feeling sleepy, upper right stomach pain, yellowing of the skin or eyes, or dark urine, please talk with your provider right away.

                        risk-warning

                        Serious birth defects

                        Don't take divalproex (Depakote) if you're pregnant. Divalproex (Depakote) can cause serious problems to unborn babies, such as neural tube defects or lower mental ability, if taken by mothers during pregnancy. If you're able to become pregnant, your provider might recommend you to use a form of birth control or take folic acid while you're taking divalproex (Depakote). If you become pregnant while taking divalproex (Depakote), let your provider know right away. Don't stop taking this medication on your own since it might raise your risk of seizures. You’re also encouraged to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This registry monitors and collects information about your and your baby’s health. Learn more about this registry by calling 1-888-233-2334.

                        risk-warning

                        Serious pancreas problems

                        Though rare, people who took divalproex (Depakote) have reported inflammation of the pancreas (pancreatitis). This can happen at any point during treatment with this medication. Some common symptoms of an inflamed pancreas are upper stomach pain, fever, nausea, and vomiting. If you start to feel any of these symptoms, contact your provider right away.

                        risk-warning

                        Suicidal behavior and thoughts

                        • Risk factors: History of depression | Taking anti-epileptics

                          As with many other anti-epileptics, divalproex (Depakote) can raise the risk of suicidal thoughts or actions as early as 1 week after starting treatment. The risk is higher if you've had suicidal thoughts or actions in the past. Let your friends and family know to watch out for new or worsening signs of depression or other changes in mood or behavior. Call your provider right away if any suicidal thoughts or actions occur.

                          risk-warning

                          Lower blood cell counts

                          • Risk factors: Taking higher doses of divalproex (Depakote) | Taking medications that lower blood cell counts

                            Though extremely rare, some people developed lower platelet count while taking divalproex (Depakote). This can put you at higher risk for bleeds. Your provider will typically require lab work before and while you're taking this medication to make sure it's safe for you. Let your provider know if you've symptoms of bleeding, such as abnormal bruising.

                            risk-warning

                            Higher ammonia level in blood

                            • Risk factors: History of metabolic disorders | Taking topiramate | Low body temperature

                              Divalproex (Depakote) can cause ammonia to build up in your body, especially if it's taken with topiramate. This can cause you to become more tired, unable to concentrate, or vomit. In some cases, you might also experience a drop in body temperature when your ammonia level is high. High levels of ammonia in the blood can lead to brain damage, which can be dangerous. Get medical attention right away if you notice any of these symptoms. Don't take divalproex (Depakote) if you've been told that you have a history of metabolic disorders that raise ammonia levels (e.g., urea cycle disorders).

                              risk-warning

                              Severe skin and allergic reactions

                              Divalproex (Depakote) can sometimes cause rash and other severe skin reactions. In some cases, these severe allergic reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), have happened with or without a rash. Although these reactions are rare, they can cause organ failure or blood problems. Let your provider know if you experience these reactions because they'll need to stop divalproex (Depakote) treatment and also talk with you about safer options to treat your condition. If you have a rash, blisters on your lips, skin peeling, skin pain, mouth sores, or high fever, get medical help immediately.

                              risk-warning

                              Interaction with other medications

                              Some medications can interfere with how your body gets rid of divalproex (Depakote). This can affect the amount of divalproex (Depakote) in your body, how well it works, and the risk of side effects.

                              For example, taking divalproex (Depakote) with carbapenem antibiotics can lower the amount of divalproex (Depakote) in your body and potentially cause divalproex (Depakote) to not work as well. On the other hand, taking divalproex (Depakote) with aspirin can raise the amount of divalproex (Depakote) in your body and potentially lead to more side effects. As a result, your provider will monitor your blood works closely when you take these medications together.

                              Likewise, divalproex (Depakote) can also interfere with how your body gets rid of other medications and raise your risk of side effects from those medications. For example, taking divalproex (Depakote) can raise the amount of lamotrigine (Lamictal) in your body. Taking a lower dose of lamotrigine (Lamictal) might help reduce your risk of serious side effects like rash.

                              For your safety, let your provider or pharmacist know what other medications you’re taking before and while taking divalproex (Depakote) so they can help you check for interactions.

                              dosage

                              Divalproex (Depakote) dosage forms

                              The average cost for 60 tablets of 500mg of Divalproex (Depakote) is $17.40 with a free GoodRx coupon. This is 82.59% off the average retail price of $99.94.
                              capsule
                              Capsule
                              DosageQuantityPrice as low asPrice per unit
                              125mg180 capsules$40.64$0.23
                              tablet
                              Tablet
                              DosageQuantityPrice as low asPrice per unit
                              125mg60 tablets$15.00$0.25
                              250mg60 tablets$12.00$0.20
                              500mg60 tablets$17.40$0.29

                              Typical dosing for Divalproex (Depakote)

                              Bipolar disorder (adults only)

                              • Extended-release (ER) tablets: Your provider will determine the dose based on your body weight. The typical starting dose is 25 mg/kg by mouth once daily. Your provider will raise your dose quickly to help control your mood better. The maximum dose is 60 mg/kg daily.

                              • Delayed-release (DR) tablets: The typical starting dose is 750 mg daily, split into smaller doses and taken by mouth throughout the day. Your provider will raise your dose quickly to help control your mood better. The maximum dose is 60 mg/kg (based on body weight) daily.

                              Migraine prevention (adults only)

                              • ER tablets: The typical starting dose is 500 mg by mouth once daily. The maximum dose is 1000 mg once daily.

                              • DR tablets: The typical starting dose is 250 mg by mouth twice daily. The maximum daily dose is 1000 mg.

                              Seizures (adults and children ages 10 years or older)

                              • ER tablets, DR tablets, and sprinkle capsules: Your provider will determine the dose based on your body weight. The typical starting dose ranges from 10 mg/kg to 15 mg/kg by mouth per day, depending on what type of seizure you have. Your provider will raise your dose weekly as needed to better control the seizures. The maximum daily dose is 60 mg/kg.

                              Your dose might differ if you're an older adult.

                              More on Divalproex (Depakote) dosage forms

                              interactions

                              Interactions between Divalproex (Depakote) and other drugs

                              Divalproex (Depakote) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Divalproex (Depakote). Please note that only the generic name of each medication is listed below.

                              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                              Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                              drug-cost

                              How much does Divalproex (Depakote) cost?

                              To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                              contraindications-icon

                              Divalproex (Depakote) contraindications

                              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Divalproex (Depakote) will not be safe for you to take.
                              • History of liver problems or certain liver diseases (e.g., urea cycle disorders)

                              • Have certain genetic disorders (e.g., Alpers-Huttenlocher Syndrome)

                              • Children under 2 years old at risk of certain genetic disorders (e.g., POLG (DNA polymerase gamma)) disorder)

                              • People who are pregnant or can become pregnant but aren't using contraception

                              • Treatment of migraine

                              alternatives

                              What are alternatives to Divalproex (Depakote)?

                              There are a number of medications that your doctor can prescribe in place of Divalproex (Depakote). Compare a few possible alternatives below.
                              Divalproex (Depakote)
                              Used for:
                              • Bipolar disorder

                              • Seizures (focal impaired awareness seizure, absence seizure)

                              • Migraine prevention

                              $12.00 Lowest GoodRx priceView Prices
                              Used for:
                              • Seizures (partial seizures, tonic-clonic seizures, Lennox-Gastaut syndrome)

                              • Migraine prevention

                              $1.80 Lowest GoodRx priceView Prices
                              Used for:
                              • Seizures (partial seizures, tonic-clonic seizures)

                              • Seizures of Lennox-Gastaut syndrome - immediate-release only

                              • Bipolar disorder - immediate-release only

                              $9.00 Lowest GoodRx priceView Prices
                              latest news

                              What is the latest news about Divalproex (Depakote)?

                              images

                              Divalproex (Depakote) images

                              Blue Oval M945 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Blue, Oval Tablet Imprinted With "M945".Blue Oval M945 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Red-Pink, Oblong Tablet Imprinted With "Ul 500".Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Pink Oval D 86 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Pink, Oval Tablet Imprinted With "D 86".Pink Oval D 86 - Divalproex Sodium 500mg Delayed-Release Tablet
                              White Oval 500 And Apo 048 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is White, Oval Tablet Imprinted With "500" And "Apo 048".White Oval 500 And Apo 048 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Pink Oval 798 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Pink, Oval Tablet Imprinted With "798".Pink Oval 798 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Red-Pink, Oblong Tablet Imprinted With "Ul 500".Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Red-Pink, Oblong Tablet Imprinted With "Ul 500".Red-Pink Oblong Ul 500 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Blue Oval 513 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Blue, Oval Tablet Imprinted With "513".Blue Oval 513 - Divalproex Sodium 500mg Delayed-Release Tablet
                              Blue Oval 513 - Divalproex Sodium 500mg Delayed-Release Tablet
                              This medicine is Blue, Oval Tablet Imprinted With "513".Blue Oval 513 - Divalproex Sodium 500mg Delayed-Release Tablet

                              Get savings updates for Divalproex (Depakote)

                              Receive price alerts, news, and other messages from GoodRx about Divalproex (Depakote) and other healthcare topics and relevant savings offers.

                              By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                              References

                              Best studies we found

                              Ali, R., et al. (2023). Hyperammonemia. StatPearls.

                              Allen, M. J., et al. (2023). GABA receptor. StatPearls.

                              Amneal Pharmaceuticals LLC. (2023). DIVALPROEX SODIUM tablet, extended release [package insert]. DailyMed.

                              View All References (9)
                              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                              Was this page helpful?

                              Browse medications

                              View All

                              Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.