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Compare Lyrica vs. Remeron

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lyrica (pregabalin) and Remeron (mirtazapine) are both prescription medications, but they are used for different conditions and belong to different classes. Lyrica is an antiepileptic that treats nerve pain from diabetes, shingles, and spinal cord injuries, as well as fibromyalgia and partial-onset seizures. It is taken 2 or 3 times a day and can cause dizziness and drowsiness. Remeron, on the other hand, is an atypical antidepressant used to treat major depressive disorder (MDD) in adults. It is taken once daily, usually at night, and can cause sleepiness and weight gain. Lyrica is a controlled substance due to its potential for addiction, while Remeron is not. Additionally, Lyrica is available in both capsule and oral solution forms, whereas Remeron comes in oral tablets and orally disintegrating tablets. Both medications have generic versions available.

  • Pregabalin (Lyrica)
    Mirtazapine (Remeron)
  • Pregabalin (Lyrica)
    Mirtazapine (Remeron)

  • Summary of Lyrica vs. Remeron

    Summary for Antiepileptic
    Prescription only

    Pregabalin (Lyrica) treats pain caused by nerve damage and fibromyalgia in adults. It can be used with other medications to prevent seizures for both adults and children. Pregabalin (Lyrica) is taken by mouth, typically 2 or 3 times a day. It's available as a capsule and oral solution. Some of the more common side effects of this medication include dizziness and drowsiness.

    Summary for Atypical antidepressant
    Prescription only

    Mirtazapine (Remeron) is an atypical antidepressant (or more specifically, tetracyclic antidepressant). It's used to treat major depressive disorder (MDD) in adults. Mirtazapine (Remeron) is available as an oral tablet and orally disintegrating tablet (ODT) that's taken once daily, typically at night. Some common side effects of this medication include sleepiness and dry mouth. Mirtazapine (Remeron) can also raise your appetite and put you at risk for weight gain.

  • Indications of Lyrica vs. Remeron

    Indications for
    •Nerve pain from diabetes (diabetic peripheral neuropathy), shingles (postherpetic neuralgia), or spinal cord injury
    •Fibromyalgia
    •Partial-onset seizures
    Indications for
    •Major depressive disorder (MDD) in adults

  • Pros and Cons of Lyrica vs. Remeron

    Pros and Const for Antiepileptic
    Pros
    •Works well to relieve nerve pain caused by diabetes, shingles, and spinal cord injuries
    •Available in a capsule and oral solution
    •Used in combination with other anti-seizure drugs to treat partial-onset seizures
    •Available as a lower-cost generic
    Cons
    •Can cause dizziness and drowsiness
    •Must avoid drinking alcohol
    •Not recommended for breastfeeding females
    •Can cause weight gain
    Pros and Const for Atypical antidepressant
    Pros
    •Taken by mouth once daily
    •Available as a dissolvable tablet for those who can't swallow pills
    •Less likely to cause sexual side effects compared SSRIs
    •Available as a lower-cost generic
    Cons
    •Can take up to 2 months before you feel the the full benefits
    •More likely than other antidepressants to cause weight gain
    •Can cause sleepiness
    •Risk of withdrawal symptoms if you suddenly stop taking it

  • Common Side Effects of Lyrica vs. Remeron

    Common Side Effects for
    •Dizziness (8-29%)
    •Drowsiness (4-16%)
    •Swelling of hands, feet, arms, or legs (4-12%)
    •Dry mouth (2-7%)
    •Weight gain (4-6%)
    Common Side Effects for
    •Sleepiness (54%)
    •Dry mouth (25%)
    •Feeling more hungry (17%)
    •Constipation (13%)
    •Weight gain (12%)
    •Weakness (8%)
    •Dizziness (7%)

  • Warnings of Lyrica vs. Remeron

    Common Side Effects for
    •Allergic reactions and severe swelling
    •Suicidal thoughts and behavior
    •Difficulty driving and concentrating
    •Breathing problems
    •Swelling in the limbs and weight gain
    •Withdrawal symptoms and risk of seizures
    •Possible risk of bleeds (from low platelet levels)
    •Possible risk of muscle breakdown
    Common Side Effects for
    •Worsening depression, suicidal thoughts, and unusual behavior
    •Higher risk of infection (from low white blood cell count)
    •Serotonin syndrome
    •Withdrawal
    •Risk factors: Stopping mirtazapine (Remeron) suddenly
    •Not for bipolar disorder
    •Glaucoma
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Severe allergic and skin reactions
    •Difficulty concentrating and extreme sleepiness
    •Seizures
    •Low blood sodium levels
    •Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

  • Prices with our coupons for Lyrica vs. Remeron

    Learn more about Pregabalin
    Learn more about Mirtazapine

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