Compare Cymbalta vs. Lyrica

Cymbalta (duloxetine) and Lyrica (pregabalin) are both prescription medications, but they treat different conditions and belong to different drug classes. Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor) used to treat depression, anxiety, and various types of long-term pain, including diabetic neuropathy and fibromyalgia. It works by increasing serotonin and norepinephrine levels in the brain. Lyrica, on the other hand, is an antiepileptic medication used to treat nerve pain from diabetes, shingles, spinal cord injury, and fibromyalgia. If used with other anti-seizure medications, it can also treat partial-onset seizures. It is thought to work by lowering certain chemicals in the brain to relieve pain and prevent seizures. Cymbalta is typically taken once daily, while Lyrica is taken two or three times a day. Cymbalta is not a controlled substance, whereas Lyrica is a Schedule V controlled substance due to its potential for addiction and dependence. Both medications can cause dizziness and drowsiness, but Lyrica is more likely to cause weight gain and swelling of the limbs.