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Compare Tofranil vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Imipramine (Tofranil) and duloxetine (Cymbalta) are both used to treat depression, but they belong to different classes of medications. Imipramine is a tricyclic antidepressant (TCA) that also helps with bedwetting in children, while duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) that treats anxiety, diabetic neuropathy, fibromyalgia, and long-term pain in addition to depression. Imipramine can cause side effects like sleepiness, dizziness, and dry mouth, and it may take 1 to 2 months to feel its full benefits. Duloxetine, on the other hand, can cause nausea, headache, and dry mouth, and it may take several weeks to feel its full effects. Both medications can lead to withdrawal symptoms if stopped abruptly, but duloxetine is also associated with a risk of liver damage and serotonin syndrome. However, imipramine can cause glaucoma. Both medications are available as low-cost generics.

Imipramine
Duloxetine (Cymbalta)
Imipramine
Duloxetine (Cymbalta)
Summary of Tofranil vs. Cymbalta
Summary for Tricyclic antidepressant
Prescription only
Imipramine is a medication that's used to treat depression. It can also temporarily help with bedwetting in children at night. Imipramine belongs to a class of medications called tricyclic antidepressants (TCAs). There are two different forms of the medication: imipramine hydrochloride and imipramine pamoate. They used to be available under the brand name Tofranil but are now only sold as generic versions. The dosage generally depends on why you need imipramine, how severe your symptoms are, and your age. It's generally not a first-choice option because it can cause a lot of side effects, like sleepiness, dizziness, dry mouth, and changes in weight.
Summary for SNRI
Prescription only
Duloxetine (Cymbalta) is used to treat depression, anxiety, and some forms of long-term pain. This medication is an antidepressant that's called an SNRI or serotonin and norepinephrine reuptake inhibitor. The dosage is typically one capsule by mouth once daily (or twice daily for some people with depression). Side effects can include nausea, headache, and dry mouth. If you need to stop the medication for any reason, your prescriber will lower your dose slowly over time to prevent withdrawal symptoms like anxiety and trouble sleeping.
Indications of Tofranil vs. Cymbalta
Indications for

•Depression

•Bedwetting in children (imipramine hydrochloride only)

Indications for

•Major depressive disorder in adults

•Generalized anxiety disorder in people age 7 years and older

•Diabetic neuropathy (nerve pain caused by high blood sugar) in adults

•Fibromyalgia in people age 13 years and older

•Long-term pain in the muscles, bones, joints, or tendons in adults
Pros and Cons of Tofranil vs. Cymbalta
Pros and Const for Tricyclic antidepressant
Pros

•Available as a lower-cost generic

•Can take with or without food

•Dose can be adjusted by your provider based on how well the medication is working for you

•For bedwetting, only needs to be taken right before bedtime

Cons

•Can cause a lot of side effects, including blurry vision, dry mouth, and eye pain

•Can cause withdrawal symptoms if you stop taking it too suddenly after long-term use

•Has a risk for suicidal thoughts and behavior

•Not a good option for people with a history of heart problems

Pros and Const for SNRI
Pros

•Can treat several conditions, so might be good for people with multiple conditions

•Helps lower nerve pain from diabetes and other forms of long-term pain

•Can take at any time of day (as long as you're consistent)

•Available as a lower-cost generic

Cons

•Can take several weeks before you feel the full effects of the medication on your mood

•Might not be a good option for people who drink heavily or have liver or kidney problems

•Can cause higher risk of suicidal thoughts and behavior in people 24 years and younger

•Might raise your risk of bleeding
Common Side Effects of Tofranil vs. Cymbalta
Common Side Effects for
In adults (with depression)

•Dry mouth

•Blurry vision

•Nausea

•Vomiting

•Constipation

•Sleepiness

•Dizziness

•Confusion

•Anxiety

•Restlessness

In children (with bedwetting problems)

•Nervousness

•Sleep problems

•Tiredness

•Stomach upset

Common Side Effects for

•Nausea (23%)

•Headache (14%)

•Dry mouth (13%)

•Drowsiness (10%)

•Feeling tired (9%)

•Trouble sleeping (9%)

•Dizziness (9%)

•Constipation (9%)

•Diarrhea (9%)

•Low appetite (7%)

•A lot of sweating (6%)

•Stomach pain (5%)
Warnings of Tofranil vs. Cymbalta
Common Side Effects for

•Worsening depression, suicidal thoughts, and unusual behavior

•Not for use alone in bipolar disorder

•Risk of heart problems, heart attack, or stroke

•Glaucoma

•Higher risk of falls

•Seizures

Common Side Effects for

•Suicidal thoughts and behavior

•Liver damage

•Changes in blood pressure and risk of falls

•Serotonin syndrome

•Higher bleeding risk

•Severe skin reaction

•Withdrawal symptoms

•Mania

•Low sodium levels

•Sexual problems
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Compare Tofranil vs. Cymbalta

Key takeaways

Summary of Tofranil vs. Cymbalta

Indications of Tofranil vs. Cymbalta

Pros and Cons of Tofranil vs. Cymbalta

Common Side Effects of Tofranil vs. Cymbalta

Warnings of Tofranil vs. Cymbalta

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