Key takeaways
Imipramine (Tofranil) and protriptyline (Vivactil) are both tricyclic antidepressants (TCAs) used to treat depression, but they have some key differences. Imipramine is also used to treat bedwetting in children, while protriptyline is not. Imipramine comes in two forms: imipramine hydrochloride and imipramine pamoate, which differ in how quickly they release the medication. Protriptyline, on the other hand, needs to be taken 3 to 4 times a day, making it less convenient. Both medications can cause side effects like dizziness, dry mouth, and sleepiness, but imipramine can make your skin more sensitive to the sun. Both medications are available as lower-cost generics and should be taken with caution, especially in older adults or those with a history of heart problems.
