Key takeaways
Imipramine (Tofranil) and gabapentin (Neurontin) are both prescription medications, but they belong to different medication classes and have different uses. Imipramine, a tricyclic antidepressant (TCA), is primarily used to treat depression and bedwetting in children, but is sometimes used off-label for nerve pain. Gabapentin is an antiepileptic approved for treating nerve pain from shingles and as an add-on treatment for partial seizures. Both are available as a generic. Imipramine comes as a capsule and tablet, whereas gabapentin is available as a tablet, capsule, and liquid. Imipramine is typically taken once daily, often at bedtime, while gabapentin is usually taken three times a day. Imipramine can cause a lot of side effects, including dry mouth, dizziness, and weight changes, whereas gabapentin often causes dizziness and sleepiness. Both medications can lead to withdrawal symptoms if stopped abruptly. Imipramine interacts with sedatives and MAOIs, while gabapentin can cause dangerously slow breathing if taken with benzodiazepines, opioids, or alcohol.
