Compare Cymbalta vs. Effexor XR

Cymbalta (duloxetine) and Effexor (venlafaxine) are both SNRIs (serotonin and norepinephrine reuptake inhibitors) used to treat depression and anxiety, but they have some differences. Cymbalta is also approved to treat diabetic neuropathy, fibromyalgia, and long-term pain, while Effexor is used for social anxiety disorder and panic disorder. Cymbalta is typically taken once daily, while Effexor can be taken either as an immediate-release or extended-release form, with the immediate-release form needing multiple doses per day. Both medications can cause withdrawal symptoms if stopped suddenly, but withdrawal symptoms are more severe with Effexor. Cymbalta can cause liver damage, especially if you drink alcohol, while Effexor can raise your blood pressure, particularly at higher doses. Both medications are available as lower-cost generics.