Compare Pristiq vs. Celexa

Desvenlafaxine (Pristiq) and citalopram (Celexa) are both medications used to treat depression in adults, but they belong to different drug classes. Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI), while citalopram is a selective serotonin reuptake inhibitor (SSRI). Desvenlafaxine works by increasing both serotonin and norepinephrine levels in the brain, whereas citalopram only increases serotonin levels. Desvenlafaxine is typically taken once a day and is available in a tablet form, while citalopram is also taken once daily and comes in tablet, capsule, and liquid forms. Both medications can take several weeks to show their full effects, but desvenlafaxine may raise your blood pressure, making it less suitable if you have heart problems. Citalopram, on the other hand, can cause a serious heart rhythm problem called QT prolongation. Both medications can cause withdrawal symptoms if stopped suddenly and have a risk of worsening depression and suicidal thoughts, especially in people under 24 years old. Both medications are available in brand and lower-cost generic versions.