Compare Cymbalta vs. Wellbutrin XL

Cymbalta (duloxetine) and Wellbutrin (bupropion) are both medications used to treat depression, but they have some key differences. Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor) that also treats anxiety, diabetic neuropathy, fibromyalgia, and long-term pain. It works by increasing serotonin and norepinephrine levels in the brain. Wellbutrin, on the other hand, is an atypical antidepressant that is also used for seasonal affective disorder (SAD). It works primarily by boosting norepinephrine and dopamine levels. Cymbalta is typically taken once daily. Wellbutrin is available in different formulations, including immediate-release, sustained-release, and extended-release, which affects how often you take it. Wellbutrin is less likely to cause sexual side effects and weight gain compared to Cymbalta, but it is not suitable for people with a history of seizures or eating disorders. Both medications can take several weeks to show their full effects and have potential side effects, including the risk of suicidal thoughts, especially in younger people. Additionally, both are available in lower-cost generic forms.