Key takeaways
Cymbalta (duloxetine) and Celexa (citalopram) are both medications used to treat depression, but they belong to different drug classes. Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor) that also treats anxiety, diabetic neuropathy, fibromyalgia, and long-term pain. Celexa, on the other hand, is an SSRI (selective serotonin reuptake inhibitor) and is primarily used for depression. Cymbalta can be taken once or twice daily, while Celexa is typically taken once daily. Both medications can cause side effects like nausea and dry mouth, but Cymbalta has a broader range of side effects, including headache and drowsiness. Both medications can cause withdrawal symptoms if stopped abruptly. Celexa has a lower risk of weight gain compared to Cymbalta. Additionally, both medications are available in generic forms, making them more affordable.
