Serotonin and norepinephrine reuptake inhibitors (SNRIs) are used to treat a variety of mental health conditions, such as depression and anxiety. Some can also treat certain types of pain. SNRIs work by increasing the levels of serotonin and norepinephrine, two chemicals that help regulate mood and pain. Common SNRIs include duloxetine (Cymbalta), venlafaxine (Effexor XR), and desvenlafaxine (Pristiq). You can discuss with your healthcare provider to find the best option for you.