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Drizalma Sprinkle Coupon - Drizalma Sprinkle 30mg capsule

Drizalma Sprinkle

duloxetine
Used for Depression, Anxiety, Diabetic Neuropathy
Used for Depression, Anxiety, Diabetic Neuropathy

Drizalma Sprinkle (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It's taken by adults to treat depression and certain types of pain, such as fibromyalgia and nerve pain. It can taken by both adults and children for anxiety. Drizalma Sprinkle (duloxetine) comes as a capsule that's taken by mouth, typically once to twice daily. The capsule can also be opened up and the pellets sprinkled over and eaten with applesauce. Some of the more common side effects of Drizalma Sprinkle (duloxetine) include nausea, dry mouth, and headache. Drizalma Sprinkle (duloxetine) is only available as a brand-name medication.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on September 4, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Drizalma Sprinkle (duloxetine)?

What is Drizalma Sprinkle (duloxetine) used for?

How Drizalma Sprinkle (duloxetine) works

Drizalma Sprinkle (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). The exact way it works to ease pain and improve mood isn't well-understood. But Drizalma Sprinkle (duloxetine) is thought to help regulate mood, behavior, and pain by raising the levels of serotonin and norepinephrine in the brain.

Are you looking for information on duloxetine (Cymbalta) instead?

Drug Facts

Common BrandsDrizalma Sprinkle
Drug ClassSNRI
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$245.16(save 16.64%)
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What are the side effects of Drizalma Sprinkle (duloxetine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (18-23%)
  • Headache (14-18%)
  • Weight loss (14% in children)
  • Dry mouth (6-14%)
  • Stomach pain (5-13%)
  • Sleepiness (9-11%)
  • Tiredness (7-11%)
  • Lower appetite (6-10%)
  • Constipation (9% in adults)
  • Dizziness (8-9%)
  • Hard to sleep (7-10%)
  • Diarrhea (6-9%)
  • Vomiting (3-9%)
  • Excessive sweating (6% in adults)

Other Side Effects

  • Blurred vision
  • Agitation
  • Tremor
  • Anxiety
  • Erectile dysfunction
  • Low sex drive
  • Upper respiratory tract infections
  • Muscle pain
  • Flushing
  • Throat pain
  • Cough

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Suicidal thoughts and behavior
  • Liver failure: itchy skin, feeling bloated, nausea, right upper stomach pain, dark urine, yellow skin or eyes, feeling tired, feeling confused, not wanting to eat
  • Serotonin syndrome: agitation, hallucinations, confusion, coma, fast heart rate, sudden changes in blood pressure, dizziness, sweating, blushing, high body temperature, tremor, stiffness, muscle jerks, or seizures
  • Severe skin reactions: skin blisters, peeling rash, sores in the mouth, or hives
  • Withdrawal symptoms: nausea, diarrhea, sweating, anxiety, agitation, dizziness, confusion, headache, trouble sleeping, and seizures
  • Severe bleeding or bruising: bruising that doesn't improve, black-colored stools, pink or red-colored urine, coughing up or vomiting blood, unusual bleeding from the nose or gums
  • Low sodium levels: headaches, trouble concentrating, memory problems, weakness, confusion, hallucinations
  • Seizures

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

area rash

blindness

blistering, peeling, or loosening of the skin

blurred vision

change in consciousness

chills

clay-colored stools

cold sweats

confusion

convulsions

dark urine

decreased urine output

decreased vision

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

eye pain

fainting

fast or irregular heartbeat

general tiredness or weakness

hives or welts, itching, or skin rash

hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue

increased thirst

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of consciousness

red skin lesions, often with a purple center

red, irritated eyes

redness of the skin

sores, ulcers, or white spots in the mouth or on the lips

swelling of the face, ankles, or hands

tearing

tightness in the chest

unpleasant breath odor

upper right stomach pain

vomiting of blood

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation

diarrhea

fever

loss of bladder control

muscle spasm or jerking of all extremities

overactive reflexes

poor coordination

restlessness

shivering

sleepiness or unusual drowsiness

sudden loss of consciousness

sweating

talking or acting with excitement you cannot control

trembling or shaking

twitching

unusual tiredness or weakness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

cough

difficulty having a bowel movement (stool)

dry mouth

ear congestion

frequent urination

headache

lack or loss of strength

loss of appetite

loss of voice

muscle aches

nausea

sleepiness or unusual drowsiness

sneezing

sore throat

stuffy or runny nose

sweating increased

trouble sleeping

weight loss

Less common

Abnormal orgasm

acid or sour stomach

belching

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in taste

change or problem with discharge of semen

decreased interest in sexual intercourse

difficulty with moving

feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest

heartburn

inability to have or keep an erection

indigestion

longer than usual time to ejaculation of semen

loose stools

loss in sexual ability, desire, drive, or performance

loss of taste

muscle cramps, pains, or stiffness

shakiness in the legs, arms, hands, or feet

stomach discomfort or upset

sudden sweating

swollen joints

trembling or shaking of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Drizalma Sprinkle (duloxetine)

thumbs-up

Pros

Capsules can be opened and its contents sprinkled onto applesauce, so good for people who have a hard time swallowing pills

Can be taken once or twice daily

Can be taken with or without food

Can help with several different conditions, so good for people who have multiple symptoms

thumbs-down

Cons

Only available as a brand-name medication

Not recommended for people with serious liver or kidney problems or certain types of glaucoma

Risk of suicidal thoughts and behavior for children and young adults

Can't use Drizalma Sprinkle (duloxetine) within 14 days of also taking a MAOI medication because of risk for serotonin syndrome

pharmacist-tips

Pharmacist tips for Drizalma Sprinkle (duloxetine)

pharmacist

  • Don't crush or chew Drizalma Sprinkle (duloxetine) capsules because doing so will damage the pellets inside and affect how the medication works. Swallow the capsule whole.

    • If you can't swallow Drizalma Sprinkle (duloxetine) whole, you can open the capsule and sprinkle the pellets inside over applesauce. You can also mix the pellets with water and give the mixture through a nasogastric tube (NG).

      • To take Drizalma Sprinkle (duloxetine) with applesauce, open the capsule and sprinkle the pellets onto a small amount of applesauce (about one tablespoonful). It's important to take this mixture right away. Don't try to save it for later because having the pellets sit too long on top of food might affect how they work in your body.

        • To take Drizalma Sprinkle (duloxetine) through a nasogastric tube (NG), open the capsule and add the pellets to an all plastic catheter tip syringe. Then, add 50 mL of water and gently shake the syringe for about 10 seconds. Give the mixture through a 12 French or larger NG tube. If there are still pellets left in the syringe, add a little extra water (about 15 mL) to rinse out the syringe.

          • Drizalma Sprinkle (duloxetine) might cause dizziness or sleepiness, so don't drive or do anything that needs a lot of focus and attention until you know how this medication affects you.

            • Let your prescriber know if you have a hard time urinating or emptying your bladder because it might be caused by Drizalma Sprinkle (duloxetine).

              • Don't drink alcohol while taking Drizalma Sprinkle (duloxetine). This medication can cause side effects such as sleepiness and liver damage. Drinking alcohol at the same time can worsen these side effects and raise your risk for falls or liver failure. If you drink alcohol regularly or have liver problems, let your prescriber know.

                • Drizalma Sprinkle (duloxetine) can cause sexual side effects, including problems with ejaculation and low sexual desire. Let your healthcare team know if you experience these side effects and they can talk with you about your options, such as lower the dose of Drizalma Sprinkle (duloxetine) or considering other medications.

                  • Your healthcare team might ask you to check your blood pressure regularly while you're taking Drizalma Sprinkle (duloxetine). Some people have noticed their blood pressure rising after starting this medication. If your blood pressure becomes too high, your care team might lower your dose of Drizalma Sprinkle (duloxetine) or ask you to consider other options.

                    • If you have diabetes, make sure to check your blood sugar regularly while taking Drizalma Sprinkle (duloxetine). Some people have reported higher blood sugar levels after starting Drizalma Sprinkle (duloxetine).

                      • Stopping Drizalma Sprinkle (duloxetine) too suddenly can cause withdrawal symptoms such as nausea, agitation, and dizziness. If you want to stop Drizalma Sprinkle (duloxetine), speak to your prescriber about how to do so safely by lowering your dosage slowly over time.

                        faqs

                        Frequently asked questions about Drizalma Sprinkle (duloxetine)

                        How long can you take Drizalma Sprinkle (duloxetine) for nerve pain?
                        Continue to take Drizalma Sprinkle (duloxetine) as prescribed by your healthcare team. Current guidelines for nerve pain related to diabetes doesn't recommend a set duration of treatment. Your healthcare team will typically ask you to take this medication as long as it's working well to treat your nerve pain and you're not experiencing any serious side effects. Keep in mind that when you first start Drizalma Sprinkle (duloxetine), it can take up to 3 months before you experience more noticeable relief from nerve pain. So your healthcare team might ask to you to try Drizalma Sprinkle (duloxetine) for 3 months to understand whether this medication works well for you.
                        Is Drizalma Sprinkle (duloxetine) the same as duloxetine (Cymbalta)?
                        Both Drizalma Sprinkle (duloxetine) and duloxetine (Cymbalta) are delayed-release forms of duloxetine that are approved to treat the same medical conditions. The main difference is how they're taken. While both Drizalma Sprinkle (duloxetine) and duloxetine (Cymbalta) capsules can be swallowed whole, only Drizalma Sprinkle (duloxetine) capsules can be opened up and the pellets sprinkled over foods like applesauce. So Drizalma Sprinkle (duloxetine) might be a better option for people who have a hard time swallowing a regular pill. Talk with your healthcare team if you have more questions about either of these medications.
                        When do you take Drizalma Sprinkle (duloxetine)?
                        Drizalma Sprinkle (duloxetine) is typically taken by mouth once or twice daily, which will depend on your prescriber's instructions. If you take this medication once daily, you can take it either in the morning or at night, but you're recommended to take it around the same time each day. If you take Drizalma Sprinkle (duloxetine) in the morning and it makes you very drowsy, ask your prescriber about taking it in the evening instead.
                        Can you take Drizalma Sprinkle (duloxetine) and gabapentin (Neurontin) together?
                        Only take Drizalma Sprinkle (duloxetine) with gabapentin (Neurontin) if both medications are prescribed by your healthcare team. Also, ask your care team to go over the possible risks of taking both medications together. While Drizalma Sprinkle (duloxetine) and gabapentin (Neurontin) aren't known to have serious interactions, these medications can cause similar side effects, including dizziness, dry mouth, and sexual problems. Ask your healthcare team if you have specific questions about Drizalma Sprinkle (duloxetine) and gabapentin (Neurontin).
                        Can I take acetaminophen (Tylenol) with Drizalma Sprinkle (duloxetine)?
                        Acetaminophen (Tylenol) and Drizalma Sprinkle (duloxetine) aren't known to have serious medication interactions. But this combination might not be safe to take for certain people. For example, both medications have a risk of causing or worsening liver problems. If you're not sure whether it's appropriate for you to take acetaminophen (Tylenol) with Drizalma Sprinkle (duloxetine), talk with your healthcare team.
                        Can you take ibuprofen ((Advil) with Drizalma Sprinkle (duloxetine)?
                        Ask your healthcare team if you can take ibuprofen (Advil) with Drizalma Sprinkle (duloxetine). Taking these medications together can raise your risk of bleeding and bruising. But your prescriber might suggest this combination as an option if they think the benefit is greater than the risk for harm. If you're taking ibuprofen (Advil) with Drizalma Sprinkle (duloxetine), tell your care team right away if you notice bruises that won't go away or bleeding that's difficult to stop.
                        Is Drizalma Sprinkle (duloxetine) an MAOI?
                        No, Drizalma Sprinkle (duloxetine) isn't a monoamine oxidase inhibitor (MAOI); it's a selective serotonin and norepinephrine reuptake inhibitor (SNRI). While Drizalma Sprinkle (duloxetine) isn't a MAOI, it can interact with MAOI medications. Never take Drizalma Sprinkle (duloxetine) with MAOI medications at the same time, or within 2 weeks of each other. you must wait 14 days before starting Drizalma Sprinkle (duloxetine). Taking them too close together can lead to a dangerous side effect called serotonin syndrome.
                        Is Drizalma Sprinkle (duloxetine) an antidepressant?
                        Yes, selective serotonin and norepinephrine reuptake inhibitors (SNRI) like Drizalma Sprinkle (duloxetine) are first-choice medications for depression. Drizalma Sprinkle (duloxetine) has other uses too, like treating anxiety, nerve pain, and fibromyalgia. Speak with your HCP to see if Drizalma Sprinkle (duloxetine) is right for you.
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                        What are the risks and warnings for Drizalma Sprinkle (duloxetine)?

                        Drizalma Sprinkle (duloxetine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Suicidal thoughts and behaviors

                        • Risk factors: People ages 24 years and younger

                          Medications for depression, including Drizalma Sprinkle (duloxetine), can raise the risk of suicidal thoughts and behavior in children and young adults. Make sure your family members or loved ones are aware of this risk so they can let you know if they notice any changes in your mood, especially during your first few months of treatment or when the dose changes. Let your prescriber know if your depression gets worse or if you experience new or worsening suicidal thoughts because you might need to change to a different medication

                          risk-warning

                          Blood pressure changes and risk of falls

                          • Risk factors: Taking other medications that lower blood pressure or affect balance | Taking more than 60 mg per day of Drizalma Sprinkle (duloxetine) | Older adults

                            Drizalma Sprinkle (duloxetine) can suddenly lower your blood pressure, especially when you change from a lying or sitting position to a standing position. This can put you at risk for falling and fainting. Your risk might be higher when you first start Drizalma Sprinkle (duloxetine) or when there's a dosage change. Let your prescriber if you feel dizzy or faint while taking this medication because you might need a lower dose or change to a different medication.

                            risk-warning

                            Bleeding risk

                            • Risk factors: Taking aspirin, NSAIDs, warfarin, or other blood thinners | Taking other medications that affect serotonin

                              Drizalma Sprinkle (duloxetine) can raise the risk of bleeding, especially if you take it with other medications that can cause bleeding, such as non-steroidal anti-inflammatory drugs (NSAIDs) and warfarin (Coumadin). Let your prescriber know your full medication history before starting Drizalma Sprinkle (duloxetine) to see if this medication is safe for you. Get medical help right away if you notice bruises that won't go away, bleeding that's difficult to stop, blood in your urine, or dark-colored stool.

                              risk-warning

                              Serious liver problems

                              • Risk factors: Liver problems | Drinking alcohol

                                Rarely, Drizalma Sprinkle (duloxetine) can cause liver failure, which can be life-threatening. If you experience signs of liver problems, you might need to stop this medication. Let your prescriber know right away if you experience fever, tiredness, loss of appetite, nausea, vomiting, stomach pain, dark urine, or yellowing of the skin or eyes. They might ask you to stop taking Drizalma Sprinkle (duloxetine) and talk with you about other options.

                                risk-warning

                                Serotonin syndrome

                                • Risk factors: Taking medications that raise serotonin levels | Taking medications that prevent the breakdown of serotonin

                                  Drizalma Sprinkle (duloxetine) can cause a life-threatening condition called serotonin syndrome, where too much serotonin builds up in your body. The risk is higher when you take other medications that also raise serotonin levels. Get emergency medical help if you experience symptoms of serotonin syndrome, like agitation, sweating, muscle spasms.

                                  risk-warning

                                  Severe skin reactions

                                  In some rare cases, Drizalma Sprinkle (duloxetine) can cause potentially life-threatening skin reactions, called Stevens-Johnson Syndrome. Stop taking Drizalma Sprinkle (duloxetine) and let your care team know right away if you get any blisters, peeling rash, painful skin ulcers, or other skin reactions.

                                  risk-warning

                                  Withdrawal

                                  • Risk factors: Stopping Drizalma Sprinkle (duloxetine) suddenly

                                    Stopping Drizalma Sprinkle (duloxetine) too suddenly can cause withdrawal symptoms such as nausea, diarrhea, sweating, anxiety, agitation, and dizziness. If you want to stop Drizalma Sprinkle (duloxetine), speak to your prescriber about how to do so safely by lowering your dosage slowly over time.

                                    risk-warning

                                    Low sodium levels

                                    • Risk factors: Older adults | Taking water pills | Not enough fluids

                                      Drizalma Sprinkle (duloxetine) can cause very low sodium levels in your blood. Your risk is higher if you've lost a lot of fluids from your body from things such as taking water pills or not drinking enough water. Let your prescriber know if you have symptoms of low sodium levels, such as headache, difficulty concentrating, memory problems, confusion, weakness, or unsteadiness.

                                      risk-warning

                                      Sexual problems

                                      Some adults who took Drizalma Sprinkle (duloxetine) experienced sexual problems, such as erectile dysfunction and low sex drive. Contact your HCP if you notice any bothersome sexual problems while you're taking Drizalma Sprinkle (duloxetine).

                                      risk-warning

                                      Mania

                                      • Risk factors: Personal or family history of bipolar disorder

                                        Let your healthcare team know if you or someone in your family have bipolar disorder because Drizalma Sprinkle (duloxetine) might not be appropriate for you. Treating someone with bipolar disorder with an antidepressant alone can cause a manic episode (great excitement, euphoria, delusions, and overactivity). Talk to your prescriber right away if you notice unusual changes in your behavior after you take Drizalma Sprinkle (duloxetine). This medication isn't approved for treating bipolar depression.

                                        dosage

                                        Drizalma Sprinkle (duloxetine) dosage forms

                                        The average cost for 30 capsules of 30mg of Drizalma Sprinkle (duloxetine) is $228.91 with a free GoodRx coupon. This is 6.63% off the average retail price of $245.16.
                                        capsule
                                        Capsule
                                        DosageQuantityPrice as low asPrice per unit
                                        20mg30 capsules$204.47$6.82
                                        30mg30 capsules$228.91$7.63
                                        40mg30 capsules$204.38$6.81
                                        60mg30 capsules$214.76$7.16

                                        Typical dosing for Drizalma Sprinkle (duloxetine)

                                        • Depression: The typical starting dose is 30 mg by mouth once a day, 20 mg twice daily, or 30 mg twice daily. The usual dose is 60 mg by mouth daily.

                                        • Anxiety: The typical starting dose and dosing range is 30 mg to 60 mg by mouth once daily.

                                        • Diabetic neuropathy: The typical dose is 60 mg by mouth once daily.

                                        • Fibromyalgia and long-term pain in muscles, bones, and joints: The typical starting dose is 30 mg by mouth once daily. The maximum dose is 60 mg by mouth daily.

                                        interactions

                                        Interactions between Drizalma Sprinkle (duloxetine) and other drugs

                                        Drizalma Sprinkle (duloxetine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Drizalma Sprinkle (duloxetine). Please note that only the generic name of each medication is listed below.

                                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                        drug-cost

                                        How much does Drizalma Sprinkle (duloxetine) cost?

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                                        contraindications-icon

                                        Drizalma Sprinkle (duloxetine) contraindications

                                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Drizalma Sprinkle (duloxetine) will not be safe for you to take.
                                        alternatives

                                        What are alternatives to Drizalma Sprinkle (duloxetine)?

                                        There are a number of medications that your doctor can prescribe in place of Drizalma Sprinkle (duloxetine). Compare a few possible alternatives below.
                                        Drizalma Sprinkle (duloxetine)
                                        Used for:
                                        $204.38 Lowest GoodRx priceView Prices
                                        Duloxetine (Cymbalta)
                                        Used for:
                                        $10.20 Lowest GoodRx priceView Prices
                                        Venlafaxine
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                                        $8.34 Lowest GoodRx priceView Prices
                                        images

                                        Drizalma Sprinkle (duloxetine) images

                                        Blue And White Rg54 Rg54 - Drizalma Sprinkle 30mg Delayed-Release Capsule
                                        This medicine is Blue And White Capsule Imprinted With "Rg54 Rg54".Blue And White Rg54 Rg54 - Drizalma Sprinkle 30mg Delayed-Release Capsule

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                                        References

                                        Best studies we found

                                        Sun Pharmaceutical Industries, Inc. (2024). Dirzalma Sprinkle- duloxetine capsule, delayed release [package insert]. DailyMed.

                                        Snyder, M. J., et al. (2016). Treating painful diabetic peripheral neuropathy: An update. American Family Physician.

                                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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