Drizalma Sprinkle (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It's taken by adults to treat depression and certain types of pain, such as fibromyalgia and nerve pain. It can taken by both adults and children for anxiety. Drizalma Sprinkle (duloxetine) comes as a capsule that's taken by mouth, typically once to twice daily. The capsule can also be opened up and the pellets sprinkled over and eaten with applesauce. Some of the more common side effects of Drizalma Sprinkle (duloxetine) include nausea, dry mouth, and headache. Drizalma Sprinkle (duloxetine) is only available as a brand-name medication.
Drizalma Sprinkle (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). The exact way it works to ease pain and improve mood isn't well-understood. But Drizalma Sprinkle (duloxetine) is thought to help regulate mood, behavior, and pain by raising the levels of serotonin and norepinephrine in the brain.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Abdominal or stomach pain
area rash
blindness
blistering, peeling, or loosening of the skin
blurred vision
change in consciousness
chills
clay-colored stools
cold sweats
confusion
convulsions
dark urine
decreased urine output
decreased vision
difficulty with swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
fast or irregular heartbeat
general tiredness or weakness
hives or welts, itching, or skin rash
hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
increased thirst
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of consciousness
red skin lesions, often with a purple center
red, irritated eyes
redness of the skin
sores, ulcers, or white spots in the mouth or on the lips
swelling of the face, ankles, or hands
tearing
tightness in the chest
unpleasant breath odor
upper right stomach pain
vomiting of blood
yellow eyes and skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Agitation
loss of bladder control
muscle spasm or jerking of all extremities
overactive reflexes
poor coordination
restlessness
shivering
sleepiness or unusual drowsiness
sudden loss of consciousness
sweating
talking or acting with excitement you cannot control
trembling or shaking
twitching
unusual tiredness or weakness
vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Body aches or pain
difficulty having a bowel movement (stool)
ear congestion
headache
lack or loss of strength
loss of appetite
loss of voice
muscle aches
sleepiness or unusual drowsiness
stuffy or runny nose
sweating increased
trouble sleeping
Less common
Abnormal orgasm
acid or sour stomach
belching
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
change in taste
change or problem with discharge of semen
decreased interest in sexual intercourse
difficulty with moving
feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
inability to have or keep an erection
indigestion
longer than usual time to ejaculation of semen
loose stools
loss in sexual ability, desire, drive, or performance
loss of taste
muscle cramps, pains, or stiffness
shakiness in the legs, arms, hands, or feet
stomach discomfort or upset
sudden sweating
swollen joints
trembling or shaking of the hands or feet
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Continue to take Drizalma Sprinkle (duloxetine) as prescribed by your healthcare team. Current guidelines for nerve pain related to diabetes doesn't recommend a set duration of treatment. Your healthcare team will typically ask you to take this medication as long as it's working well to treat your nerve pain and you're not experiencing any serious side effects. Keep in mind that when you first start Drizalma Sprinkle (duloxetine), it can take up to 3 months before you experience more noticeable relief from nerve pain. So your healthcare team might ask to you to try Drizalma Sprinkle (duloxetine) for 3 months to understand whether this medication works well for you.
Both Drizalma Sprinkle (duloxetine) and duloxetine (Cymbalta) are delayed-release forms of duloxetine that are approved to treat the same medical conditions. The main difference is how they're taken. While both Drizalma Sprinkle (duloxetine) and duloxetine (Cymbalta) capsules can be swallowed whole, only Drizalma Sprinkle (duloxetine) capsules can be opened up and the pellets sprinkled over foods like applesauce. So Drizalma Sprinkle (duloxetine) might be a better option for people who have a hard time swallowing a regular pill. Talk with your healthcare team if you have more questions about either of these medications.
Drizalma Sprinkle (duloxetine) is typically taken by mouth once or twice daily, which will depend on your prescriber's instructions. If you take this medication once daily, you can take it either in the morning or at night, but you're recommended to take it around the same time each day. If you take Drizalma Sprinkle (duloxetine) in the morning and it makes you very drowsy, ask your prescriber about taking it in the evening instead.
Only take Drizalma Sprinkle (duloxetine) with gabapentin (Neurontin) if both medications are prescribed by your healthcare team. Also, ask your care team to go over the possible risks of taking both medications together. While Drizalma Sprinkle (duloxetine) and gabapentin (Neurontin) aren't known to have serious interactions, these medications can cause similar side effects, including dizziness, dry mouth, and sexual problems. Ask your healthcare team if you have specific questions about Drizalma Sprinkle (duloxetine) and gabapentin (Neurontin).
Acetaminophen (Tylenol) and Drizalma Sprinkle (duloxetine) aren't known to have serious medication interactions. But this combination might not be safe to take for certain people. For example, both medications have a risk of causing or worsening liver problems. If you're not sure whether it's appropriate for you to take acetaminophen (Tylenol) with Drizalma Sprinkle (duloxetine), talk with your healthcare team.
Ask your healthcare team if you can take ibuprofen (Advil) with Drizalma Sprinkle (duloxetine). Taking these medications together can raise your risk of bleeding and bruising. But your prescriber might suggest this combination as an option if they think the benefit is greater than the risk for harm. If you're taking ibuprofen (Advil) with Drizalma Sprinkle (duloxetine), tell your care team right away if you notice bruises that won't go away or bleeding that's difficult to stop.
No, Drizalma Sprinkle (duloxetine) isn't a monoamine oxidase inhibitor (MAOI); it's a selective serotonin and norepinephrine reuptake inhibitor (SNRI). While Drizalma Sprinkle (duloxetine) isn't a MAOI, it can interact with MAOI medications. Never take Drizalma Sprinkle (duloxetine) with MAOI medications at the same time, or within 2 weeks of each other. you must wait 14 days before starting Drizalma Sprinkle (duloxetine). Taking them too close together can lead to a dangerous side effect called serotonin syndrome.
Yes, selective serotonin and norepinephrine reuptake inhibitors (SNRI) like Drizalma Sprinkle (duloxetine) are first-choice medications for depression. Drizalma Sprinkle (duloxetine) has other uses too, like treating anxiety, nerve pain, and fibromyalgia. Speak with your HCP to see if Drizalma Sprinkle (duloxetine) is right for you.
Drizalma Sprinkle (duloxetine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Medications for depression, including Drizalma Sprinkle (duloxetine), can raise the risk of suicidal thoughts and behavior in children and young adults. Make sure your family members or loved ones are aware of this risk so they can let you know if they notice any changes in your mood, especially during your first few months of treatment or when the dose changes. Let your prescriber know if your depression gets worse or if you experience new or worsening suicidal thoughts because you might need to change to a different medication
Drizalma Sprinkle (duloxetine) can suddenly lower your blood pressure, especially when you change from a lying or sitting position to a standing position. This can put you at risk for falling and fainting. Your risk might be higher when you first start Drizalma Sprinkle (duloxetine) or when there's a dosage change. Let your prescriber if you feel dizzy or faint while taking this medication because you might need a lower dose or change to a different medication.
Drizalma Sprinkle (duloxetine) can raise the risk of bleeding, especially if you take it with other medications that can cause bleeding, such as non-steroidal anti-inflammatory drugs (NSAIDs) and warfarin (Coumadin). Let your prescriber know your full medication history before starting Drizalma Sprinkle (duloxetine) to see if this medication is safe for you. Get medical help right away if you notice bruises that won't go away, bleeding that's difficult to stop, blood in your urine, or dark-colored stool.
Drizalma Sprinkle (duloxetine) can cause a life-threatening condition called serotonin syndrome, where too much serotonin builds up in your body. The risk is higher when you take other medications that also raise serotonin levels. Get emergency medical help if you experience symptoms of serotonin syndrome, like agitation, sweating, muscle spasms.
In some rare cases, Drizalma Sprinkle (duloxetine) can cause potentially life-threatening skin reactions, called Stevens-Johnson Syndrome. Stop taking Drizalma Sprinkle (duloxetine) and let your care team know right away if you get any blisters, peeling rash, painful skin ulcers, or other skin reactions.
Stopping Drizalma Sprinkle (duloxetine) too suddenly can cause withdrawal symptoms such as nausea, diarrhea, sweating, anxiety, agitation, and dizziness. If you want to stop Drizalma Sprinkle (duloxetine), speak to your prescriber about how to do so safely by lowering your dosage slowly over time.
Drizalma Sprinkle (duloxetine) can cause very low sodium levels in your blood. Your risk is higher if you've lost a lot of fluids from your body from things such as taking water pills or not drinking enough water. Let your prescriber know if you have symptoms of low sodium levels, such as headache, difficulty concentrating, memory problems, confusion, weakness, or unsteadiness.
Some adults who took Drizalma Sprinkle (duloxetine) experienced sexual problems, such as erectile dysfunction and low sex drive. Contact your HCP if you notice any bothersome sexual problems while you're taking Drizalma Sprinkle (duloxetine).
Let your healthcare team know if you or someone in your family have bipolar disorder because Drizalma Sprinkle (duloxetine) might not be appropriate for you. Treating someone with bipolar disorder with an antidepressant alone can cause a manic episode (great excitement, euphoria, delusions, and overactivity). Talk to your prescriber right away if you notice unusual changes in your behavior after you take Drizalma Sprinkle (duloxetine). This medication isn't approved for treating bipolar depression.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 20mg | 30 capsules | $221.11 | $7.37 |
| 30mg | 30 capsules | $221.11 | $7.37 |
| 40mg | 30 capsules | $221.11 | $7.37 |
| 60mg | 30 capsules | $221.11 | $7.37 |
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Drizalma Sprinkle (duloxetine) will not be safe for you to take.