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Lidoderm vs. Desipramine

Lidocaine 5% patch (Lidoderm) is a prescription medication used to relieve nerve pain caused by a shingles infection, also called postherpetic neuralgia (PHN). It's a local anesthetic that works by numbing your nerves to help reduce pain. You apply the patch directly to the painful area of your skin once a day, and it can be worn for up to 12 hours in a 24-hour period. Common side effects include temporary skin irritation, redness, and a mild burning sensation where the patch is applied.

• Nerve pain caused by shingles (postherpetic neuralgia)

• Blisters
• Bruising
• Burning sensation
• Changes in skin color
• Rash or redness
• Swelling
• Peeling or flaking skin
• Itching
• Small bumps or spots
• Tiny red or purple dots under the skin
• Tingling or numbness in the area

• Blood problem (methemoglobinemia)
• Absorbing too much medication
• Accidental poisoning in children or pets

Desipramine (Norpramin) is an tricyclic antidepressant (TCA). It's FDA-approved to treat depression in adults, but it's not a first-choice medication for this condition. Desipramine (Norpramin) is taken by mouth, typically once per day. Side effects of this medication include sleepiness, confusion, and weight gain. It's best to avoid drinking alcohol while taking desipramine (Norpramin) because doing so can worsen side effects.

• Depression

• Dry mouth
• Blurry vision
• Nausea
• Vomiting
• Constipation
• Sleepiness
• Dizziness
• Confusion
• Anxiety
• Restlessness

• Worsening depression, suicidal thoughts, and unusual behavior
• Not for use alone in bipolar disorder
• Serotonin syndrome
• Risk of heart problems, heart attack, or stroke
• Glaucoma
• Higher risk of falls
• Seizures