Key takeaways
Meloxicam (Mobic) and diclofenac are nonsteroidal anti-inflammatory drugs (NSAIDs). They’re only available by prescription. They’re both FDA approved for arthritis-related pain, but diclofenac is also approved for other types of pain, such as pain from menstrual cramps or migraines. Both medications come in several prescription-only oral forms, but diclofenac is also available as an over-the-counter topical gel called Voltaren Arthritis Pain gel. Mobic is typically taken once a day while oral diclofenac is usually taken 2 to 4 times a day. NSAIDs like meloxicam and diclofenac can cause an upset stomach, headache, and swelling as common side effects. More serious risks include bleeding or ulcers. They also raise the risk of heart attack. However, topical diclofenac doesn’t usually have the same risks as oral NSAIDs. These medications also have similar drug interactions. For example, It’s best to avoid mixing either medication with alcohol.
