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Compare Meloxicam vs. Naproxen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Meloxicam and naproxen (Naprosyn, EC-Naprosyn) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation associated with conditions like rheumatoid arthritis and osteoarthritis. However, they differ in several ways. Meloxicam is available in various forms, including capsules, tablets, oral suspension, and an injection (administered only by a healthcare professional), while naproxen is available as tablets and oral liquid suspension. Meloxicam is typically taken once daily, whereas naproxen is usually taken two to three times per day. Meloxicam is more selective for cyclooxygenase (COX)-2, which may result in fewer stomach and kidney side effects compared to naproxen, which blocks both COX-1 and COX-2. Common side effects of meloxicam and naproxen include diarrhea, heartburn, and upset stomach. Both medications can increase the risk of stomach bleeding, especially when taken with alcohol or other NSAIDs. Both medications are available as a lower-cost generics, and naproxen also has an over-the-counter form (Aleve).

  • Meloxicam
    Naproxen (Naprosyn)
  • Meloxicam
    Naproxen (Naprosyn)

  • Summary of Meloxicam vs. Naproxen

    Summary for NSAID
    Prescription only

    Meloxicam is a prescription non-steroidal anti-inflammatory drug (NSAID). It's used for different types of arthritis pain. It comes as capsules, tablets and a liquid. All forms are for adults, but some are also for children of certain age and weight. Meloxicam is taken by mouth once a day. The dosage depends on your arthritis type, the form of meloxicam you're using, and age and weight for children. Common side effects include diarrhea, joint pain, and stomach upset. Like all NSAIDs, it can raise the risk of stomach bleeds. Meloxicam is a generic medication; its brand name Mobic is no longer available.

    Summary for NSAID
    Prescription only

    Prescription-strength naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children to relieve pain and symptoms of certain conditions that cause inflammation, such as rheumatoid arthritis, osteoarthritis, or gout. Naproxen (Naprosyn) works by blocking specific proteins that cause inflammation and pain. Naproxen (Naprosyn) comes as tablet and liquid suspension that are taken by mouth, typically 2 to 3 times per day. Some common side effects include heartburn, stomach pain, and nausea.

  • Indications of Meloxicam vs. Naproxen

    Indications for
    •Osteoarthritis (OA) - capsules, tablets, and oral liquid
    •Rheumatoid arthritis (RA) - tablets and oral liquid
    •Juvenile rheumatoid arthritis (JRA) - tablets and oral liquid
    Indications for
    •Rheumatoid arthritis (RA)
    •Osteoarthritis (OA)
    •Ankylosing spondylitis (AS) (arthritis of the spine)
    •Polyarticular juvenile idiopathic arthritis (arthritis in children)
    •Tendonitis and bursitis
    •Gout attacks
    •Pain
    •Menstrual cramps

  • Pros and Cons of Meloxicam vs. Naproxen

    Pros and Const for NSAID
    Pros
    •Only taken once a day
    •Might cause less stomach upset and other stomach problems than some other NSAIDs
    •Also available as a liquid for people who have trouble swallowing pills
    Cons
    •Available by prescription only
    •Might not be the best option for older adults or people with kidney, heart, liver, or bleeding problems
    •Can't switch easily between capsules, tablets, and liquid (can't be substituted for one another)
    Pros and Const for NSAID
    Pros
    •Works well for treating pain and inflammation
    •Effects last longer than other NSAIDs, such as ibuprofen (Advil)
    •Available as a liquid for people who have a hard time swallowing pills
    Cons
    •Can cause stomach bleeding or stomach ulcers
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

  • Common Side Effects of Meloxicam vs. Naproxen

    Common Side Effects for
    •Headache
    •Diarrhea
    •Indigestion
    •Nausea
    •Stomach pain
    •Joint pain
    •Flu-like symptoms
    Common Side Effects for

    The following side effects were reported in 3-9% of people in clinical studies:

    •Heartburn
    •Stomach pain
    •Constipation
    •Nausea
    •Dizziness
    •Drowsiness
    •Headache
    •Itchy skin
    •Bruising
    •Ringing in the ears
    •Swelling
    •Shortness of breath

  • Warnings of Meloxicam vs. Naproxen

    Common Side Effects for
    •Risk of stomach ulcers and stomach bleeding
    •Risk of heart attack and stroke
    •High blood pressure
    •Swelling and risk of heart failure
    •Liver problems
    •Kidney damage
    •High potassium levels
    •Risk of general bleeding and anemia
    •Severe allergic reactions and skin reactions
    •Worsening asthma in certain people
    •Harm to an unborn baby
    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions
    •Not for use in pregnant or breastfeeding females

  • Prices with our coupons for Meloxicam vs. Naproxen

    Learn more about Meloxicam
    Learn more about Naproxen

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