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Compare Celebrex vs. Naproxen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Celecoxib (Celebrex) and naproxen (Naprosyn) are prescription medications used to relieve pain and inflammation, but have some differences between them. Celecoxib has a lower risk of stomach-related side effects compared to naproxen. Celecoxib is typically taken once or twice a day, while naproxen is usually taken two to three times a day. Serious side effects of these medications inlcude an increased risk of heart attack and stroke. Both medications are available in a generic form, and naproxen also has an over-the-counter (OTC) version known as Aleve. Additionally, celecoxib is not recommended for people with a sulfa allergy, and both medications should be avoided in people who are pregnant.

  • Celebrex (celecoxib)
    Naproxen (Naprosyn)
  • Celebrex (celecoxib)
    Naproxen (Naprosyn)

  • Summary of Celebrex vs. Naproxen

    Summary for COX-2 selective NSAID
    Prescription only

    Celecoxib, also known by the brand name Celebrex, is a prescription pain medication that's used to temporarily relieve aches and pains from certain conditions, such as different types of arthritis. Celebrex (celecoxib) is a non-steroidal anti-inflammatory drug (NSAID), but it has a lower risk of causing stomach upset than other medications in its drug class, such as naproxen. The dosage for Celebrex (celecoxib) is typically once or twice a day. It's recommended to avoid taking this medication with alcohol since it can raise your risk for stomach bleeding. Other side effects include headache, indigestion, and diarrhea.

    Summary for NSAID
    Prescription only

    Prescription-strength naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children to relieve pain and symptoms of certain conditions that cause inflammation, such as rheumatoid arthritis, osteoarthritis, or gout. Naproxen (Naprosyn) works by blocking specific proteins that cause inflammation and pain. Naproxen (Naprosyn) comes as tablet and liquid suspension that are taken by mouth, typically 2 to 3 times per day. Some common side effects include heartburn, stomach pain, and nausea.

  • Indications of Celebrex vs. Naproxen

    Indications for
    •Osteoarthritis (OA)
    •Rheumatoid arthritis (RA)
    •Juvenile rheumatoid arthritis (JRA)
    •Ankylosing spondylitis (AS)
    •Sudden pain
    •Menstrual cramps
    Indications for
    •Rheumatoid arthritis (RA)
    •Osteoarthritis (OA)
    •Ankylosing spondylitis (AS) (arthritis of the spine)
    •Polyarticular juvenile idiopathic arthritis (arthritis in children)
    •Tendonitis and bursitis
    •Gout attacks
    •Pain
    •Menstrual cramps

  • Pros and Cons of Celebrex vs. Naproxen

    Pros and Const for COX-2 selective NSAID
    Pros
    •Can use for different types of arthritis
    •Fewer stomach side effects compared to some other NSAIDs
    •Safe to take for children 2 years and older with RA
    •Can open capsules and mix contents with applesauce, so it's convenient for people with difficulty swallowing pills
    Cons
    •Can raise the risk of heart attack and stroke
    •Not recommended during second and third trimesters of pregnancy
    •Not recommended for use if you have severe liver disease
    •Might not be safe for people with a sulfa allergy
    Pros and Const for NSAID
    Pros
    •Works well for treating pain and inflammation
    •Effects last longer than other NSAIDs, such as ibuprofen (Advil)
    •Available as a liquid for people who have a hard time swallowing pills
    Cons
    •Can cause stomach bleeding or stomach ulcers
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

  • Common Side Effects of Celebrex vs. Naproxen

    Common Side Effects for

    Adults

    •Headache (16%)
    •Indigestion (9%)
    •Upper respiratory infection (8%)
    •Diarrhea (6%)
    •Sinus infection (congestion, runny nose; 5%)
    •Belly pain (4%)

    Children

    •Headache (13%)
    •Fever (8%)
    •Belly pain (4-8%)
    •Cough (7%)
    •Nausea (7%)
    •Diarrhea (5%)
    •Common cold (stuffy nose, sneezing; 5%)
    Common Side Effects for

    The following side effects were reported in 3-9% of people in clinical studies:

    •Heartburn
    •Stomach pain
    •Constipation
    •Nausea
    •Dizziness
    •Drowsiness
    •Headache
    •Itchy skin
    •Bruising
    •Ringing in the ears
    •Swelling
    •Shortness of breath

  • Warnings of Celebrex vs. Naproxen

    Common Side Effects for
    •Heart attack and stroke
    •Stomach bleeding and ulcers
    •Liver problems
    •High blood pressure and heart failure
    •Kidney damage and high potassium levels
    •Severe allergic reactions
    •Severe asthma attack
    •Harm to unborn babies
    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions
    •Not for use in pregnant or breastfeeding females

  • Prices with our coupons for Celebrex vs. Naproxen

    Learn more about Celebrex
    Learn more about Naproxen

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