Key takeaways
Celecoxib (Celebrex) and naproxen (Naprosyn) are prescription medications used to relieve pain and inflammation, but have some differences between them. Celecoxib has a lower risk of stomach-related side effects compared to naproxen. Celecoxib is typically taken once or twice a day, while naproxen is usually taken two to three times a day. Serious side effects of these medications inlcude an increased risk of heart attack and stroke. Both medications are available in a generic form, and naproxen also has an over-the-counter (OTC) version known as Aleve. Additionally, celecoxib is not recommended for people with a sulfa allergy, and both medications should be avoided in people who are pregnant.
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