Key takeaways
Celecoxib (Celebrex) and ibuprofen (Advil, Motrin) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation. Celecoxib causes fewer stomach issues compared to ibuprofen. Celecoxib is available only by prescription, while ibuprofen can be purchased over-the-counter (OTC) or by prescription, depending on the strength. Celecoxib is usually taken once or twice a day, whereas ibuprofen is typically taken every 4 to 8 hours. Both are used to treat various types of arthritis pain and menstrual cramps. But ibuprofen can also used for general pain, fever, and minor aches. Taking these medications can increase your risk of heart attack, stroke, and stomach bleeding, however, celecoxib is considered to have a lower risk of causing stomach ulcers.
