Key takeaways
Indomethacin (Indocin) and meloxicam (Mobic) are both NSAIDs used to treat arthritis pain, but they have some key differences. Indomethacin is available as a tablet, liquid, and rectal suppository, while meloxicam comes in oral forms like capsules, tablets, and liquid, as well as an injectable form. Indomethacin is typically used multiple times a day, whereas meloxicam is usually taken once daily. Meloxicam tends to cause fewer stomach and kidney side effects because it blocks COX-2 more than COX-1, unlike indomethacin, which blocks both COX-1 and COX-2. Both medications require a prescription and are not safe during pregnancy.
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