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Indocin vs. Feldene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Indocin (indomethacin) and Feldene (piroxicam) are both NSAIDs used to treat arthritis, but they have some key differences. Indocin is available as a tablet, suspension, and rectal suppository, while Feldene is taken orally as a capsule. Indocin is typically used multiple times a day, whereas Feldene is usually taken once daily. Indocin treats a wider range of conditions, including gouty arthritis and shoulder pain, while Feldene is mainly for osteoarthritis and rheumatoid arthritis. Both medications can cause serious side effects like stomach bleeding and heart problems, but Indocin has additional risks such as worsening mental health issues. Both are available as lower-cost generics.

Indomethacin

(Indocin)

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Piroxicam

(Feldene)

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Summary for Indocin

Prescription only

Indomethacin (Indocin) is an NSAID that's used to treat different types of arthritis, including arthritis related to gout. It's also used to treat conditions that cause shoulder pain. This medication can be used in people 15 years of age and older; it hasn't been studied in younger children. The oral form of indomethacin (Indocin) is available as capsules (both immediate-release and extended-release) and a liquid. The dosage for immediate-release formulations is typically 2 to 4 times a day, and the dosage for extended-release capsules is once a day. Common side effects include headache, dizziness, and stomach upset.

Indications for Indocin

Pros and Cons for Indocin

Pros

  • Can relieve pain and swelling
  • Available in fast-acting formulations and a longer-acting, extended-release capsule
  • Dose can be adjusted by your provider if needed
  • Liquid version is a good option for people who have trouble swallowing pills

Cons

  • Might not be the best option for long-term use because of safety risks
  • Most forms are taken 2 to 4 times a day
  • Not a good choice if you have kidney or liver problems
  • Can raise your risk of blood clots, heart attack, or stroke (similar to other NSAIDs)

Common Side Effects for Indocin

Note: Side effects listed here are for immediate-release indomethacin. Side effects for extended-release capsules might differ.

  • Headache (12%)
  • Nausea (up to 9%)
  • Upset stomach (up to 9%)
  • Dizziness (up to 9%)

Warnings for Indocin

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Liver problems
  • Kidney damage and high potassium levels
  • Severe allergic reactions
  • Severe asthma attack
  • Worsening of nervous system and mental health problems
  • Harm to unborn babies

Summary for Feldene

Prescription only

Piroxicam (Feldene) is a nonsteroidal anti-inflammatory drug (NSAID) that works well to relieve symptoms of arthritis, such as joint pain, swelling, and stiffness. It's a capsule that's taken by mouth, typically once daily. Possible side effects include diarrhea, nausea, vomiting, and rash.

Indications for Feldene

Pros and Cons for Feldene

Pros

  • Can be taken once daily
  • Taken by mouth
  • Available as a lower-cost generic

Cons

  • Not available as a liquid
  • Can take 2 to 3 months to get the full effects
  • Can cause serious complications, including stomach bleeding and kidney problems, if taken for a long period of time.

Common Side Effects for Feldene

  • Nausea and vomiting
  • Constipation
  • Passing gas
  • Stomach pain
  • Diarrhea
  • Headache
  • Dizziness
  • Swelling or fluid buildup
  • Rash
  • Ringing in the ears

Please note: The side effects below were reported by up to 10% of people who took piroxicam (Feldene) in clinical trials.

Warnings for Feldene

  • Heart attack and stroke
  • Stomach bleeding and ulcers
  • High blood pressure and heart failure
  • Kidney damage and high potassium levels
  • Liver damage
  • Severe allergic reactions
  • Not for use in pregnant or breastfeeding females

Prices with our coupons for Indocin vs. Feldene

Price Card Drug Icon
Indomethacin1 vial / 1mg
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Piroxicam30 capsules / 10mg
$17.89$41.51
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