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Compare Indocin vs. Feldene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Indocin (indomethacin) and Feldene (piroxicam) are both NSAIDs used to treat arthritis, but they have some key differences. Indocin is available as a tablet, suspension, and rectal suppository, while Feldene is taken orally as a capsule. Indocin is typically used multiple times a day, whereas Feldene is usually taken once daily. Indocin treats a wider range of conditions, including gouty arthritis and shoulder pain, while Feldene is mainly for osteoarthritis and rheumatoid arthritis. Both medications can cause serious side effects like stomach bleeding and heart problems, but Indocin has additional risks such as worsening mental health issues. Both are available as lower-cost generics.

  • Indomethacin (Indocin) suppository
    Piroxicam (Feldene)
  • Indomethacin (Indocin) suppository
    Piroxicam (Feldene)

  • Summary of Indocin vs. Feldene

    Summary for NSAID
    Prescription only

    Indomethacin (Indocin) suppository is an NSAID that's used to treat different types of arthritis and conditions that cause pain in the shoulder. It helps lower inflammation and relieve pain. As a suppository, it's inserted into the rectum, typically 2 to 4 times a day depending on what condition the medication is being used to treat. Side effects might include headache and stomach upset. Unlike other NSAIDs, indomethacin (Indocin) suppository isn't available over-the-counter and requires a prescription from your healthcare provider.

    Summary for NSAID
    Prescription only

    Piroxicam (Feldene) is a nonsteroidal anti-inflammatory drug (NSAID) that works well to relieve symptoms of arthritis, such as joint pain, swelling, and stiffness. It's a capsule that's taken by mouth, typically once daily. Possible side effects include diarrhea, nausea, vomiting, and rash.

  • Indications of Indocin vs. Feldene

    Indications for
    •Moderate-to-severe rheumatoid arthritis, including flare-ups
    •Moderate-to-severe ankylosing spondylitis
    •Moderate-to-severe osteoarthritis
    •Shoulder pain caused by bursitis or tendonitis
    •Gouty arthritis
    Indications for
    •Pain from osteoarthritis
    •Pain from rheumatoid arthritis

  • Pros and Cons of Indocin vs. Feldene

    Pros and Const for NSAID
    Pros
    •Good option for people who have trouble swallowing pills
    •Can treat many different types of arthritis
    •Available as a lower-cost generic
    Cons
    •Only available in one strength (50 mg), so you might need to use several suppositories if you're taking a high dose
    •Might need to take multiple times per day
    •Not available over-the-counter
    Pros and Const for NSAID
    Pros
    •Can be taken once daily
    •Taken by mouth
    •Available as a lower-cost generic
    Cons
    •Not available as a liquid
    •Can take 2 to 3 months to get the full effects
    •Can cause serious complications, including stomach bleeding and kidney problems, if taken for a long period of time.

  • Common Side Effects of Indocin vs. Feldene

    Common Side Effects for

    Note: The side effects listed here are for indomethacin capsules. Side effects for the suppositories might differ.

    •Headache
    •Dizziness
    •Nausea
    •Stomach upset
    Common Side Effects for
    •Nausea and vomiting
    •Constipation
    •Passing gas
    •Stomach pain
    •Diarrhea
    •Headache
    •Dizziness
    •Swelling or fluid buildup
    •Rash
    •Ringing in the ears

    Please note: The side effects below were reported by up to 10% of people who took piroxicam (Feldene) in clinical trials.

  • Warnings of Indocin vs. Feldene

    Common Side Effects for
    •Stomach bleeding and ulcers
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Liver problems
    •Kidney damage and high potassium levels
    •Severe allergic reactions
    •Severe asthma attack
    •Worsening of nervous system and mental health problems
    •Harm to unborn babies
    Common Side Effects for
    •Heart attack and stroke
    •Stomach bleeding and ulcers
    •High blood pressure and heart failure
    •Kidney damage and high potassium levels
    •Liver damage
    •Severe allergic reactions
    •Not for use in pregnant or breastfeeding females

  • Prices with our coupons for Indocin vs. Feldene

    Learn more about Indomethacin
    Learn more about Piroxicam

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