Key takeaways
Prednisone (Rayos, Prednisone Intensol) and Enbrel (etanercept) are both used to treat autoimmune conditions, but they are quite different in their forms and how they work. Prednisone is an oral corticosteroid available in generic form, while Enbrel is a biologic disease-modifying antirheumatic drug (DMARD) given as a subcutaneous injection and is only available as a brand-name product. Prednisone works by calming down the immune system to reduce inflammation, whereas Enbrel blocks a specific protein called tumor necrosis factor (TNF) to control inflammation. Prednisone can cause side effects like mood changes, weight gain, and sleep problems, especially with long-term use. Enbrel, on the other hand, can increase the risk of serious infections and certain cancers. Prednisone is taken daily, while Enbrel is typically injected once a week. Enbrel needs to be refrigerated, while prednisone does not. Both medications require careful monitoring by your healthcare provider.
