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Compare Skyrizi vs. Remicade

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Remicade (infliximab) are both medications used to treat autoimmune conditions like Crohn's disease, ulcerative colitis, and psoriatic arthritis. However, they belong to different medication classes. Skyrizi is an interleukin antagonist, while Remicade is a biologic disease-modifying antirheumatic drug (DMARD) that blocks tumor necrosis factor (TNF). Skyrizi is available as an injection that you can administer at home after training, whereas Remicade is given through an intravenous (IV) infusion by a healthcare professional. Skyrizi is typically dosed every 2 to 3 months, depending on the condition, while Remicade is usually given every 6 to 8 weeks. Skyrizi is only available as a brand-name medication, while Remicade has biosimilars like Avsola, Inflectra, and Renflexis. Common side effects of Skyrizi include joint pain and upper respiratory infections, while Remicade can cause nausea, headache, and infusion-related reactions. Both medications can increase the risk of infections, but Remicade also carries risks of serious conditions like cancer and heart problems.

  • Skyrizi (risankizumab)
    Remicade (infliximab)
  • Skyrizi (risankizumab)
    Remicade (infliximab)

  • Summary of Skyrizi vs. Remicade

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for Biologic DMARD
    Prescription only

    Remicade (infliximab) is an injectable medication used to treat many autoimmune conditions, including ulcerative colitis and Crohn's disease. It's given through an intravenous (IV) infusion by a healthcare provider.

  • Indications of Skyrizi vs. Remicade

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Moderate-to-severe Crohn's disease (CD)
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe rheumatoid arthritis (RA)
    •Ankylosing spondylitis (AS)
    •Psoriatic arthritis (PsA)
    •Severe plaque psoriasis (PsO)

  • Pros and Cons of Skyrizi vs. Remicade

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for Biologic DMARD
    Pros
    •Can be used for many autoimmune conditions
    •Typically only needs to be given every 6 to 8 weeks
    •Can be used in children 6 years of age and older for UC and CD
    Cons
    •Can only be given as an IV infusion by a healthcare professional
    •Can cause a lot of side effects
    •Brand name only, which can be expensive

  • Common Side Effects of Skyrizi vs. Remicade

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Infections
    •Nausea
    •Infusion-related reactions (e.g., headache, flushing, shortness of breath, rash)
    •Headache
    •Diarrhea
    •Stomach pain
    •Sore throat
    •Cough
    •Rash
    •Bronchitis
    •Indigestion
    •Tiredness
    •General pain
    •Joint pain

  • Warnings of Skyrizi vs. Remicade

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Serious or deadly infections
    •Cancer
    •Liver problems and liver failure
    •Heart problems
    •Low blood cell counts
    •Nervous system problems
    •Medications to avoid

  • Prices with our coupons for Skyrizi vs. Remicade

    Learn more about Skyrizi
    Learn more about Remicade

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