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Skyrizi vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Dupixent (dupilumab) are both biologic medications used to treat inflammatory conditions, but they belong to different medication classes and have distinct uses. Skyrizi is an interleukin antagonist used for plaque psoriasis, psoriatic arthritis, and Crohn's disease, while Dupixent is a monoclonal antibody used for eczema, asthma, and sinus congestion with nasal polyps, among other conditions. Skyrizi is typically administered as an injection every 2 to 3 months, whereas Dupixent is injected every other week or monthly, depending on the condition. Skyrizi is available in prefilled syringes, pens, and On-Body Injectors, while Dupixent comes in prefilled pens and syringes. Skyrizi's common side effects include injection site reactions, joint pain, and infections, while Dupixent may cause injection site reactions and eye inflammation. Both medications can interact with live vaccines, so it's important to discuss vaccine plans in advance with your prescriber. Skyrizi is not approved for use in children, whereas Dupixent can be used in children as young as 6 months for eczema.

Skyrizi

(risankizumab)

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Dupixent

(dupilumab)

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Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injectable medication for many inflammatory conditions. It treats plaque psoriasis in adults and children ages 6 years and up. It can also treat psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults. This medication works as an interleukin antagonist to help lower inflammation. After a few starter doses, it's given every 2 or 3 months, depending on the condition being treated. Side effects include a higher risk of infection.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after the starter doses (depends on your condition)
  • Can give maintenance doses at home as injections under the skin after proper training
  • Approved for children as young as 6 years old with plaque psoriasis

Cons

  • Must be given as an injection
  • Can raise the risk of infection
  • Might take several weeks to months to work fully

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Summary for Dupixent

Prescription only

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

Indications for Dupixent

Pros and Cons for Dupixent

Pros

  • Taken every other week or monthly for most conditions
  • Approved for some children (specific age depends on the condition)
  • Available as prefilled pens (for people ages 2 years and older)
  • Available as prefilled syringes (for people ages 6 months and older)

Cons

  • Given as an injection under the skin
  • Not used for helping with asthma attacks
  • Can cause injection reactions, such as pain, bruising, and swelling
  • Unknown if it's safe or works well while pregnant or breastfeeding

Common Side Effects for Dupixent

  • Injection site reaction (e.g., pain, swelling, bruising; 10%)
  • Eye redness or eye inflammation (10%)
  • Cold sores (4%)

Warnings for Dupixent

  • Allergic reactions
  • Eye inflammation
  • Other inflammation in the body
  • Risk of worsening of breathing problems in people with asthma or COPD
  • Risk of psoriasis
  • Joint pain and psoriatic arthritis
  • Unknown effect in people with parasitic worm infections
  • Interaction with vaccines

Prices with our coupons for Skyrizi vs. Dupixent

Price Card Drug Icon
Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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Dupixent2 cartons / 2 pens of 300mg/2ml
$4,486.66-
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