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Compare Skyrizi vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Dupixent (dupilumab) are both biologic medications used to treat inflammatory conditions, but they belong to different medication classes and have distinct uses. Skyrizi is an interleukin antagonist used for plaque psoriasis, psoriatic arthritis, and Crohn's disease, while Dupixent is a monoclonal antibody used for eczema, asthma, and sinus congestion with nasal polyps, among other conditions. Skyrizi is typically administered as an injection every 2 to 3 months, whereas Dupixent is injected every other week or monthly, depending on the condition. Skyrizi is available in prefilled syringes, pens, and On-Body Injectors, while Dupixent comes in prefilled pens and syringes. Skyrizi's common side effects include injection site reactions, joint pain, and infections, while Dupixent may cause injection site reactions and eye inflammation. Both medications can interact with live vaccines, so it's important to discuss vaccine plans in advance with your prescriber. Skyrizi is not approved for use in children, whereas Dupixent can be used in children as young as 6 months for eczema.

  • Skyrizi (risankizumab)
    Dupixent (dupilumab)
  • Skyrizi (risankizumab)
    Dupixent (dupilumab)

  • Summary of Skyrizi vs. Dupixent

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Skyrizi vs. Dupixent

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Skyrizi vs. Dupixent

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Skyrizi vs. Dupixent

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Skyrizi vs. Dupixent

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Skyrizi vs. Dupixent

    Learn more about Skyrizi
    Learn more about Dupixent

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