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Compare Skyrizi vs. Taltz

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Taltz (ixekizumab) are both interleukin antagonists used to treat inflammatory conditions like plaque psoriasis and psoriatic arthritis. However, they differ in several ways. Skyrizi is also approved for Crohn's disease, while Taltz is approved for ankylosing spondylitis and non-radiographic axial spondyloarthritis. Skyrizi is typically administered as an injection every 2 to 3 months after initial doses, whereas Taltz is injected once a month. Skyrizi is available in prefilled syringes, pens, and an On-Body Injector, while Taltz comes as a prefilled syringe and autoinjector. Both medications can increase the risk of infections, but Taltz may also cause flare-ups in people with Crohn's disease or ulcerative colitis. Common side effects for Skyrizi include joint pain and upper respiratory infections, while Taltz often causes injection site reactions and upper respiratory infections. Neither medication has a generic version available.

  • Skyrizi (risankizumab)
    Taltz (ixekizumab)
  • Skyrizi (risankizumab)
    Taltz (ixekizumab)

  • Summary of Skyrizi vs. Taltz

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for Interleukin antagonist
    Prescription only

    Taltz (ixekizumab) is an injection that's given under the skin. It helps treat inflammatory conditions, including plaque psoriasis, psoriatic arthritis, and some types of arthritis in the spine. This medication works as an interleukin antagonist to lessen inflammation in the body. You inject Taltz (ixekizumab) once a month using the prefilled syringe or autoinjector. The dose depends on the health problem you're treating. Side effects include upper respiratory infections. You also might feel pain or have redness around the injection area. Taltz (ixekizumab) is a brand-name medication.

  • Indications of Skyrizi vs. Taltz

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Moderate-to-severe plaque psoriasis in people 6 years and older
    •Psoriatic arthritis in adults
    •Ankylosing spondylitis in adults
    •Non-radiographic axial spondyloarthritis in adults

  • Pros and Cons of Skyrizi vs. Taltz

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for Interleukin antagonist
    Pros
    •Generally given once a month (might need some starter doses)
    •Available as a prefilled syringe or autoinjector for easier use
    •Can inject at home after a healthcare professional trains you (for most people)
    Cons
    •Only given as an injection under the skin
    •Raises the risk of infections
    •Might cause flare-ups in people with Crohn's disease or ulcerative colitis

  • Common Side Effects of Skyrizi vs. Taltz

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Reaction at the injection site (e.g., redness, pain; 17%)
    •Upper respiratory tract infections (14%)

  • Warnings of Skyrizi vs. Taltz

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Risk of infection
    •Caution when getting vaccines
    •Eczema-like skin reaction
    •Allergic reaction
    •Inflammatory bowel disease

  • Prices with our coupons for Skyrizi vs. Taltz

    Learn more about Skyrizi
    Learn more about Taltz

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