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Compare Dupixent vs. Fasenra

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dupixent (dupilumab) and Fasenra (benralizumab) are both injectable biologic medications used to treat inflammatory conditions, specifically asthma. However, they belong to different medication classes and have distinct uses and characteristics. Dupixent is a monoclonal antibody that treats a variety of conditions in addition to asthma, including eczema, sinus congestion with nasal polyps, and eosinophilic esophagitis, among others. Fasenra, on the other hand, is an interleukin antagonist specifically approved for severe eosinophilic asthma. Dupixent is available as a pre-filled pen and syringe, with dosing that varies based on the condition being treated, while Fasenra is available as a pen and is typically injected every month for the first three months, then every two months. Dupixent is not available in a generic form and is approved for use in children as young as 6 months for eczema, whereas Fasenra is approved for children 6 years old and older. Common side effects of Dupixent include injection site reactions and eye inflammation, while Fasenra may cause headache and sore throat. Both medications can cause serious allergic reactions and should not be used to treat asthma attacks.

Dupixent (dupilumab)
Fasenra (benralizumab)
Dupixent (dupilumab)
Fasenra (benralizumab)
Summary of Dupixent vs. Fasenra
Summary for Interleukin antagonist
Prescription only
Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.
Summary for Interleukin receptor antagonist
Prescription only
Fasenra (benralizumab) is a brand-name injectable medication. It treats severe eosinophilic asthma in people 6 years and older. The medication can also help treat eosinophilic granulomatosis with polyangiitis (EGPA) in adults. It works as an interleukin antagonist to lower inflammation and relieve symptoms. You inject the medication under the skin with the Fasenra autoinjector pen. For eosinophilic asthma, the usual dosing schedule is an injection every 4 weeks for the first 3 months, then once every 8 weeks after that. For EGPA, it's injected every 4 weeks. Side effects can include headache and sore throat.
Indications of Dupixent vs. Fasenra
Indications for

•Moderate-to-severe eczema - for people 6 months and older

•Moderate-to-severe asthma - add-on maintenance for people 6 years and older

•Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older

•Eosinophilic esophagitis - for people 1 year and older

•Prurigo nodularis (long-term itchy skin bumps) - for adults

•Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults

•Long-term hives - for people 12 years and older

Indications for

•Severe eosinophilic asthma in people 6 years and older - as an add-on treatment

•Eosinophilic granulomatosis with polyangiitis (EGPA) in adults
Pros and Cons of Dupixent vs. Fasenra
Pros and Const for Interleukin antagonist
Pros

•Taken every other week or monthly for most conditions

•Approved for some children (specific age depends on the condition)

•Available as prefilled pens (for people ages 2 years and older)

•Available as prefilled syringes (for people ages 6 months and older)

Cons

•Given as an injection under the skin

•Not used for helping with asthma attacks

•Can cause injection reactions, such as pain, bruising, and swelling

•Unknown if it's safe or works well while pregnant or breastfeeding

Pros and Const for Interleukin receptor antagonist
Pros

•Can inject at home after you get trained

•Available as an autoinjector pen for easier use at home

•Can help lower the rate of asthma attacks in people with severe eosinophilic asthma

•Can help people who have EGPA get to remission (when symptoms go away)

Cons

•Must be injected under the skin

•Not for treating asthma attacks as they're happening

•Not approved for children under 6 years old with severe eosinophilic asthma

•Not approved for children under 18 with EGPA
Common Side Effects of Dupixent vs. Fasenra
Common Side Effects for

•Injection site reaction (e.g., pain, swelling, bruising; 10%)

•Eye redness or eye inflammation (10%)

•Cold sores (4%)

Common Side Effects for

•Headache (8%)

•Sore throat (5%)

•Fever (3%)

•Rash (3%)
Warnings of Dupixent vs. Fasenra
Common Side Effects for

•Allergic reactions

•Eye inflammation

•Other inflammation in the body

•Risk of worsening of breathing problems in people with asthma or COPD

•Risk of psoriasis

•Joint pain and psoriatic arthritis

•Unknown effect in people with parasitic worm infections

•Interaction with vaccines

Common Side Effects for

•Serious allergic reactions

•Not for asthma attacks

•Avoid stopping your steroid medications suddenly

•Get parasitic worm infections treated
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Compare Dupixent vs. Fasenra

Key takeaways

Summary of Dupixent vs. Fasenra

Indications of Dupixent vs. Fasenra

Pros and Cons of Dupixent vs. Fasenra

Common Side Effects of Dupixent vs. Fasenra

Warnings of Dupixent vs. Fasenra

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