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Compare Tremfya vs. Cosentyx

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Cosentyx (secukinumab) are both monoclonal antibodies used to treat inflammatory conditions, but they work differently. Tremfya targets interleukin-23 (IL-23) and is used for moderate-to-severe plaque psoriasis and active psoriatic arthritis. Cosentyx, on the other hand, targets interleukin-17 (IL-17) and treats a wider range of conditions, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa. Tremfya is injected under the skin every 8 weeks after initial doses, while Cosentyx is aslo an injection under the skin but is typically injected monthly. Cosentyx can also be given as an IV infusion for certain conditions. Both medications can raise the risk of infections, but Cosentyx may also worsen inflammatory bowel disease symptoms.

  • Tremfya (guselkumab)
    Cosentyx (secukinumab)
  • Tremfya (guselkumab)
    Cosentyx (secukinumab)

  • Summary of Tremfya vs. Cosentyx

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Interleukin 17 (IL-17) inhibitor
    Prescription only

    Cosentyx (secukinumab) is a monoclonal antibody known as an interleukin 17 (IL-17) inhibitor. It's used to treat several inflammatory conditions, including plaque psoriasis, ankylosing spondylitis, and hidradenitis suppurativa. Cosentyx (secukinumab) comes as a pre-filled pen and syringe, and is typically injected under the skin monthly. It can also be given as an infusion through the veins by a healthcare provider for certain conditions, usually in a clinic setting. Side effects aren't common, but can include the common cold and diarrhea.

  • Indications of Tremfya vs. Cosentyx

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Plaque psoriasis (PsO) in people ages 6 years and older
    •Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
    •Hidradenitis suppurativa in adults

  • Pros and Cons of Tremfya vs. Cosentyx

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Interleukin 17 (IL-17) inhibitor
    Pros
    •Works well to treat several different inflammatory problems
    •Injected monthly (after the loading doses)
    •Available as a prefilled syringe or Sensoready pen for easy at-home injections
    •Can be used in children (for plaque psoriasis, psoriatic arthritis, and enthesitis-related arthritis)
    Cons
    •Only available as injections
    •Raises the risk of infections
    •Can worsen inflammatory bowel disease (IBD) (e.g., ulcerative colitis or Crohn's disease) symptoms
    •Pens and prefilled syringes not appropriate for those with latex allergy

  • Common Side Effects of Tremfya vs. Cosentyx

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Common cold (12%)
    •Diarrhea (4%)
    •Upper respiratory infections (3%)

    Note: Side effects listed were reported by adults who took Cosentyx (secukinumab) for PsO in clinical trials.

  • Warnings of Tremfya vs. Cosentyx

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Infections
    •Caution when getting vaccines
    •Allergic and skin reactions
    •Worsening of inflammatory bowel disease

  • Prices with our coupons for Tremfya vs. Cosentyx

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    Learn more about Cosentyx

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