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Compare Ohtuvayre vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ohtuvayre (ensifentrine) and Dupixent (dupilumab) are both prescription medications used to treat conditions related to inflammation. Ohtuvayre is specifically FDA-approved for chronic obstructive pulmonary disease (COPD), while Dupixent is used for a variety of inflammatory conditions, including COPD, asthma, and eczema. Ohtuvayre is a phosphodiesterase 3 and 4 inhibitor taken via inhalation twice daily using a nebulizer, whereas Dupixent is a monoclonal antibody administered as a subcutaneous injection every other week or monthly. Neither medication is available in a generic form. Ohtuvayre's common side effects include back pain and high blood pressure, while Dupixent cause injection site reactions and eye inflammation. Ohtuvayre should not be mixed with other medications in a nebulizer. Dupixent may interact with live vaccines, so you should avoid them while on this medication.

  • Ohtuvayre (ensifentrine)
    Dupixent (dupilumab)
  • Ohtuvayre (ensifentrine)
    Dupixent (dupilumab)

  • Summary of Ohtuvayre vs. Dupixent

    Summary for PDE3 / PDE4 Inhibitor
    Prescription only

    Ohtuvayre (ensifentrine) is an inhaled prescription medication for adults with chronic obstructive pulmonary disease (COPD). As a phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) inhibitor, it’s used to help people breathe better in the long run. This medication is inhaled by mouth through a nebulizer with a fitted mouthpiece. It's taken two times each day, once in the morning and once in the evening. As a maintenance treatment, Ohtuvayre (ensifentrine) shouldn’t be used as a replacement for your inhaled rescue medication in case of sudden breathing problems. Side effects of Ohtuvayre (ensifentrine) include back pain, high blood pressure, and diarrhea.

    Summary for Interleukin antagonist
    Prescription only

    Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

  • Indications of Ohtuvayre vs. Dupixent

    Indications for
    •Chronic obstructive pulmonary disease (COPD)
    Indications for
    •Moderate-to-severe eczema - for people 6 months and older
    •Moderate-to-severe asthma - add-on maintenance for people 6 years and older
    •Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
    •Eosinophilic esophagitis - for people 1 year and older
    •Prurigo nodularis (long-term itchy skin bumps) - for adults
    •Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
    •Long-term hives - for people 12 years and older

  • Pros and Cons of Ohtuvayre vs. Dupixent

    Pros and Const for PDE3 / PDE4 Inhibitor
    Pros
    •Can start working as early as the first day of treatment
    •Can be used alongside other COPD treatments
    •Doesn’t commonly cause side effects
    Cons
    •Must be taken twice daily
    •Risk of mental health problems
    •Must be inhaled using a nebulizer, which can be confusing to use for some people
    Pros and Const for Interleukin antagonist
    Pros
    •Taken every other week or monthly for most conditions
    •Approved for some children (specific age depends on the condition)
    •Available as prefilled pens (for people ages 2 years and older)
    •Available as prefilled syringes (for people ages 6 months and older)
    Cons
    •Given as an injection under the skin
    •Not used for helping with asthma attacks
    •Can cause injection reactions, such as pain, bruising, and swelling
    •Unknown if it's safe or works well while pregnant or breastfeeding

  • Common Side Effects of Ohtuvayre vs. Dupixent

    Common Side Effects for
    •Back pain (2%)
    •High blood pressure (2%)
    •Urinary Tract Infection (1%)
    •Diarrhea (1%)
    Common Side Effects for
    •Injection site reaction (e.g., pain, swelling, bruising; 10%)
    •Eye redness or eye inflammation (10%)
    •Cold sores (4%)

  • Warnings of Ohtuvayre vs. Dupixent

    Common Side Effects for
    •Not for use as a rescue inhaler
    •Unexpected bronchospasm
    •Changes in mood or behavior
    Common Side Effects for
    •Allergic reactions
    •Eye inflammation
    •Other inflammation in the body
    •Risk of worsening of breathing problems in people with asthma or COPD
    •Risk of psoriasis
    •Joint pain and psoriatic arthritis
    •Unknown effect in people with parasitic worm infections
    •Interaction with vaccines

  • Prices with our coupons for Ohtuvayre vs. Dupixent

    Learn more about Ohtuvayre
    Learn more about Dupixent

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