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Compare Sotyktu vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sotyktu (deucravacitinib) and Skyrizi (risankizumab) are both medications used to treat moderate-to-severe plaque psoriasis in adults. However, they belong to different medication classes and have important differences. Sotyktu is a tyrosine kinase 2 (TYK2) inhibitor taken orally once a day. It works by blocking a protein that causes inflammation. On the other hand, Skyrizi is an interleukin antagonist administered as an injection every 2 or 3 months after initial doses. It blocks proteins involved in inflammation, called interleukin-23 (IL-23). Skyrizi is also FDA-approved for psoriatic arthritis, ulcerative colitis, and Crohn's disease, while Sotyktu is only approved for plaque psoriasis. Both medications can increase the risk of an infection, including an upper respiratory infection. These medications are only available in a branded version.

  • Sotyktu (deucravacitinib)
    Skyrizi (risankizumab)
  • Sotyktu (deucravacitinib)
    Skyrizi (risankizumab)

  • Summary of Sotyktu vs. Skyrizi

    Summary for Tyrosine kinase 2 inhibitor
    Prescription only

    Sotyktu (deucravacitinib) is a medication used to treat moderate-to-severe plaque psoriasis in adults. It works as a tyrosine kinase 2 inhibitor to lessen inflammation. Sotyktu (deucravacitinib) comes as a tablet that you take once a day, with or without food. Side effects include a higher risk of infections, like upper respiratory infections. Sotyktu (deucravacitinib) is only available as a brand-name medication.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Sotyktu vs. Skyrizi

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Sotyktu vs. Skyrizi

    Pros and Const for Tyrosine kinase 2 inhibitor
    Pros
    •Taken by mouth once a day
    •Can take with or without food
    •Safe to take if you have kidney problems or mild-to-moderate liver problems
    Cons
    •Can raise the risk of infections
    •Have to get blood work done every so often to check for side effects
    •Not approved for children
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Sotyktu vs. Skyrizi

    Common Side Effects for
    •Upper respiratory infections (19%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Sotyktu vs. Skyrizi

    Common Side Effects for
    •Allergic reactions
    •Risk of infections
    •Muscle damage
    •Liver damage
    •Possible risk of cancer
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Sotyktu vs. Skyrizi

    Learn more about Sotyktu
    Learn more about Skyrizi

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