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Compare Sotyktu vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sotyktu (deucravacitinib)
    Skyrizi (risankizumab)
  • Sotyktu (deucravacitinib)
    Skyrizi (risankizumab)

  • Summary of Sotyktu vs. Skyrizi

    Summary for Tyrosine kinase 2 inhibitor
    Prescription only

    Sotyktu (deucravacitinib) is a tyrosine kinase 2 (TYK2) inhibitor that's used to treat moderate-to-severe plaque psoriasis in adults. It's a tablet that's taken by mouth once per day. Side effects include a higher risk of infections, such as upper respiratory infections and herpes simplex infections. Sotyktu (deucravacitinib) is a brand-name medication and available by prescription only.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Sotyktu vs. Skyrizi

    Indications for
    •Moderate-to-severe plaque psoriasis
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Sotyktu vs. Skyrizi

    Pros and Const for Tyrosine kinase 2 inhibitor
    Pros
    •Taken by mouth once a day
    •Can take with or without food
    •Safe to take if you have kidney problems or mild-to-moderate liver problems
    Cons
    •Can raise the risk for new or worsening infections
    •Have to get blood work periodically done during treatment to check for side effects
    •Hasn't been studied in children
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Sotyktu vs. Skyrizi

    Common Side Effects for
    •Upper respiratory infections (19%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Sotyktu vs. Skyrizi

    Common Side Effects for
    •Severe allergic reactions
    •Serious infections
    •Muscle damage
    •Liver damage
    •Possible risk of cancer
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Sotyktu vs. Skyrizi

    Learn more about Sotyktu
    Learn more about Skyrizi

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