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Compare Taltz vs. Otezla

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Taltz (ixekizumab)
    Otezla (apremilast)
  • Taltz (ixekizumab)
    Otezla (apremilast)

  • Summary of Taltz vs. Otezla

    Summary for Interleukin antagonist
    Prescription only

    Taltz (ixekizumab) is a monoclonal antibody known as an interleukin antagonist. It's used to treat inflammatory problems, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Taltz (ixekizumab) is available as a prefilled syringe and prefilled autoinjector. It's given as an injection under the skin once per month. Side effects include upper respiratory infections and injection-site reactions (e.g., pain, redness).

    Summary for PDE-4 inhibitor
    Prescription only

    Otezla (apremilast) is a tablet that's taken by mouth. It's used to treat plaque psoriasis, psoriatic arthritis, and mouth sores from Behçet’s disease. This medication belongs to the drug class called phosphodiesterase-4 (PDE-4) inhibitors. You usually start Otezla (apremilast) at a low dose. Then, the dose is slowly raised over 5 days to lower the risk of side effects like nausea and diarrhea. This medication is available as a brand-name medication. Generic versions of apremilast likely won't be available until at least 2028.

  • Indications of Taltz vs. Otezla

    Indications for
    •Moderate-to-severe plaque psoriasis in people ages 6 years and older
    •Psoriatic arthritis (PsA) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    Indications for
    •Active psoriatic arthritis in adults
    •Moderate-to-severe plaque psoriasis in people age 6 years and older weighing at least 44 lbs
    •Mouth sores from Behçet’s disease in adults

  • Pros and Cons of Taltz vs. Otezla

    Pros and Const for Interleukin antagonist
    Pros
    •Given once per month (after the first few doses)
    •Available as a prefilled syringe or autoinjector for easier use
    •Can inject at home after proper training
    Cons
    •Only given as an injection under the skin
    •Raises the risk of infections
    •Might cause flare ups in people with Crohn's disease or ulcerative colitis
    Pros and Const for PDE-4 inhibitor
    Pros
    •Taken by mouth
    •Can take with or without food
    •Dose adjustment available for people with severe kidney problems
    Cons
    •Dosing schedule can be confusing in the beginning
    •Common to have nausea or diarrhea in the beginning
    •Might not be a good option for people who've had depression or suicidal behavior

  • Common Side Effects of Taltz vs. Otezla

    Common Side Effects for
    •Reaction at the injection site (e.g., redness, pain; 17%)
    •Upper respiratory infections (14%)
    Common Side Effects for
    •Diarrhea (17%)
    •Nausea (17%)
    •Upper respiratory tract infection (e.g., common cold; 9%)
    •Headache (6%)

  • Warnings of Taltz vs. Otezla

    Common Side Effects for
    •Infections
    •Caution when getting vaccines
    •Allergic reaction
    •Inflammatory bowel disease
    Common Side Effects for
    •Allergic reaction
    •Diarrhea, nausea, and vomiting
    •Depression
    •Possible weight loss
    •Drug interactions

  • Prices with our coupons for Taltz vs. Otezla

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    Learn more about Otezla

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